Eleonora Leucci · @Eleucci
5 followers · 1 posts · Server mastodon.uno
Excited to share our work of the of the last 5 years. https://www.biorxiv.org/content/10.1101/2023.01.06.523012v1. We found that in response to the ISR, the primate-specific #lncRNA LISR customises the #ribosomes to drive translation of an immune suppressive signature. The signature includes #neoantigens translated from lncRNAs, the #immunecheckpoint receptor PDL1 and the #glycocalyx. LISR KD restores sensitivity to #immunecheckpointblockade in #melanoma and possibly in other cancers.
#lncRNA #ribosomes #neoantigens #immunecheckpoint #glycocalyx #immunecheckpointblockade #Melanoma
Søren Grubb · @Grubb
20 followers · 27 posts · Server mas.toAt the #PrecapillarySphincter and #NeurovascularUnit, I show: #EndothelialCell, #MuralCell, #Fibroblast, #Macrophage, #Astrocyte and #Neuron. Also, structures: #ContractileElement, #MyoendothelialJunction, #PinocyticVesicle, #Collagen, #Elastin, #Glycocalyx (6/15)
#glycocalyx #elastin #collagen #pinocyticvesicle #myoendothelialjunction #contractileelement #neuron #Astrocyte #macrophage #fibroblast #muralcell #endothelialcell #neurovascularunit #precapillarysphincter
Søren Grubb · @Grubb
20 followers · 18 posts · Server mas.toAt the #PrecapillarySphincter and #NeurovascularUnit, I show: #EndothelialCell, #MuralCell, #Fibroblast, #Macrophage, #Astrocyte and #Neuron. Also, structures: #ContractileElement, #MyoendothelialJunction, #PinocyticVesicle, #Collagen, #Elastin, #Glycocalyx (6/15)
#glycocalyx #elastin #collagen #pinocyticvesicle #myoendothelialjunction #contractileelement #neuron #Astrocyte #macrophage #fibroblast #muralcell #endothelialcell #neurovascularunit #precapillarysphincter