Epigenetics #PulmonaryArterialHypertension

JMJD1C a histone demethylase
⏫p-STAT3->
⏫#Glycolysis HK2/PGK1/LDHA->
⏫PA #SmoothMuscleCell Proliferation

Serum Lactate⏬by AAV2-shJMJD1C in🐭#Hypoxia-PAH
Local effect on #EndMT?

Dr H Zhao lab Cell Death Discovery 2023
https://www.nature.com/articles/s41420-023-01390-5

🌄 #Circadian nature of #Mitochondria

We examine daily changing patterns of mitochondrial function and metabolism in Drosophila in vivo in terms of their complex (I-IV) activity, #ATP production, #glycolysis, and whole fly respiration in the morning, afternoon and night.
https://www.nature.com/articles/s41598-019-48383-y

RT @ImmPRes_
did you notice that in the last release we added a feature to study protein families. For example, how about looking at the glycolytic proteins and how they change upon T cell activation in CD8s? #glycolysis #tcells #proteomics

Easily done in the heatmap section 😎

#1 of our 2022 countdown is the unique organelle - the mitochondrion.
#mitochondria #3Dbiology #glycolysis
http://ow.ly/9Tvc50Me7r3 https://twitter.com/SmartBiology3D/status/1609217912580997120/video/1