Exciting research indicates sugar boosts health benefits of antioxidants, improving their solubility and stability. This aids using fruit and veggie compounds in medicines and supplements. Scientists study bacterial fermentation and sugar biosynthesis for efficient glyco-drug development, aiming to enhance production and transportation. Learn more: https://go.digitalengineer.io/AJ. #Polyphenols #Glycosylation #HealthBenefits 🌱🍓💊

Do you know the mammalian monosaccharides? Most people who know their #aminoacids and #nucleotides answer no to this quesion... Want to learn? Download our new #glycogang #glycotime poster today! http://glyco-alberta.ca/educational-resources/ (in the for educators tab). Learn more about #glycosylation #education #biochemistry

Interesting! ST3GAL1 sialylates CD18, inducing nonspecific tissue sequestration of CAR-T cells by altering LFA-1 endocytic recycling. CAR-T cells with expression of ßII-spectrin that bind LFA-1 improve tumor-specific homing of CAR T cells. https://tinyurl.com/4w3zhvxs

#glycosylation

'Blockade of the inhibitory FcγRIIB in combination with anti–PD-L1 improved antitumor responses. Similarly, afucosylation of the IgG1 Fc region improved antitumor responses, and this was due to alterations in the tumor microenvironment.'

#immunology #immunotherapy #glycosylation

https://www.science.org/doi/10.1126/sciimmunol.add8005

Cover feature in issue 42/2:

#Golgi #oxygen sensor controlling #intestinal ‘mucin #glycosylation
by Tal Ilani, Deborah Fass and colleagues with SciStories.com

And:
Gut colonization via #GTPase-less EF-G paralog
#Yeast cells in two minds about #cellcycle start
#MASTL/#PP2A module restraining #PI3K-Akt
Zinc-dependent structural transition in ALS-mutated #SOD1
https://www.embopress.org/toc/14602075/2023/42/2

What determines specificity of #flagellin #glycosylation in #bacteria?
Patrick Viollier, Nicolas Kint et al reveal #stereoisomer selectivity wired into species-specific C-terminal domain of #FlmG #glycosyltransferases

https://www.embopress.org/doi/10.15252/embj.2022112880

"Our results suggest that, in a cellular context, Fab glycans inhibit IgG–hFcRn interaction and thus negatively affect the transplacental transfer of IgG. As Fab-glycosylated Abs are frequently associated with autoimmune and malignant disorders and may be potentially harmful, this might encompass a regulatory mechanism, limiting the half-life and transport of such Abs."

#immunology #glycosylation

https://journals.aai.org/jimmunol/article-abstract/210/2/158/237585/IgG-Fab-Glycans-Hinder-FcRn-Mediated-Placental?redirectedFrom=fulltext

@profcelentyx @cellpress Interesting... I get #IgG infusions for #immunodeficiency. Some batches cause severe knee joint pain-worse than my baseline and the joints make horrible noises. Now I'm wondering if the IgG is inflammatory sometimes? I've only started IgG a year ago so I don't know what it was like in the before times. Are there other diseases that do this or just covid? I was unaware of #glycosylation until now.

Bulk #IgG #Glycosylation Predicts #COVID19 Severity and #Vaccine #Antibody Response

@cellpress

https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01687-4

#Introduction time! I'm a professor at the #UniversityOfQueensland interested in #glycosylation #glycotime #MassSpectrometry #virology #yeast #wine and #beer! https://scmb.uq.edu.au/profile/75/benjamin-schulz

May also have traces of #chickens #cats #dogs and #fungi

#introduction to our work. Trained as an organic chemist, I found my passion for #glycotime working with @bertozzi at stanford university on understanding #raredisease #NGLY1 deficiency during my postdoc. With my team, currently located at Heinrich Heine University in Duessendorf, I use #bioorthogonal chemistry to study aberrant #glycosylation in congenital disorders of glycosylation and some types of cancer. We develop multi-modal chemical probes for #imaging and #glycoproteimics

An #introduction into our work on #glycotime! We are a lab joint between the Francis Crick Institute and the Department of Chemistry at Imperial College London. We develop what we call chemical "precision tools" to investigate protein #glycosylation. These tools are specific for individual #glycosyltransferases, #glycan subtypes or cell lines. We employ methods of #chembio including #OrgChem, protein engineering, #glycoproteomics, #imaging, #chemoenzymatic synthesis and drug discovery.