Crystal structures of the catalytic domains of S. mutans glucosyltransferases GtfB and GtfD are reported and are compared with previously determined structures of the catalytic domain of GtfC. #Glucansucrases #Glycosyltransferases #CatalyticDomains https://doi.org/10.1107/S2053230X23003199

Norbert Schormann et al.: The catalytic domains of Streptococcus mutans glucosyltransferases: a structural analysis #CatalyticDomains #Glycosyltransferases @UABNews... #IUCr http://scripts.iucr.org/cgi-bin/paper?S2053230X23003199

What determines specificity of #flagellin #glycosylation in #bacteria?
Patrick Viollier, Nicolas Kint et al reveal #stereoisomer selectivity wired into species-specific C-terminal domain of #FlmG #glycosyltransferases

https://www.embopress.org/doi/10.15252/embj.2022112880

An #introduction into our work on #glycotime! We are a lab joint between the Francis Crick Institute and the Department of Chemistry at Imperial College London. We develop what we call chemical "precision tools" to investigate protein #glycosylation. These tools are specific for individual #glycosyltransferases, #glycan subtypes or cell lines. We employ methods of #chembio including #OrgChem, protein engineering, #glycoproteomics, #imaging, #chemoenzymatic synthesis and drug discovery.