Interesting paper about the role of ST6GAL1 in prostate cancer. ST6GAL1 is upregulated in prostata cancer tissue resulting in large branched alpha-2,6 sialylated N-glycans. Secreted ST6GAL1 as a remodeller of glycans on other cells?

https://tinyurl.com/yrsm87fp

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Protein tyrosine phosphatase receptor Z (PTPRZ), highly expressed in glioblastoma, contains unique HNK-1-capped O-Man core M2 glycans synthesized by GLcNac-transferase IX. Disruption of GNT-IX gene reduces the glioblastoma growth.
https://tinyurl.com/4d9dt23r

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Interesting paper about the evolution of galectins https://tinyurl.com/mvywfcmj

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Interesting review about the role of N-glycosylation in B-cell biology: B-cell maturation and pre-BCR folding, signal transduction initiated by BCR, role of IgG N-glycosylation in ADCC, CDC, autoimmunity and aging.

https://tinyurl.com/ycknbks7

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📢 New thematic issue “Chemical glycobiology” edited by @Elisa, @RachelHevey, Benjamin Schumann and Ulrika Westerlind in the Beilstein Journal of Organic Chemistry.

📅 Submission deadline: Nov 1, 2023

👉 https://www.beilstein-journals.org/bjoc/series/127/?M=y

CarbohydrateChemistry #GlycoSciences #GlycoTime

#DiamondOpenAccess💎🔓 #BJOC

Chemokine binding to PSGL-1: tyrosine sulfation provides favorable interactions, while O-glycan branching and sialylation of glycosulfopeptides reduces the binding https://tinyurl.com/ms444pwj

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Dessert or poison? Interesting review of role of glycosylation in neurodegenrative diseas: Alzheimer's, Parkinson's, Huntington's Disease, and Amyotrophic Lateral Sclerosis. https://tinyurl.com/5dw6ftuu

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Synthetic glycolipid 7DW8-5 binds to CD1 on antigen-presenting cells, activates iNKT cells to release cytokines/chemokines. Intranasal administration blocks infection by SARS-CoV-2, RSV, influenca virus in mice. https://tinyurl.com/mups2n79
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How glycans influence T and B cell functionality in multiple aspects of adaptive immunity? Excellent review about the glycome composition of developing T and B cells explains. Must-read!

https://tinyurl.com/yckwr3ad

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Structural and mechanistic studies of the N-glycosylation machinery: from lipid-linked oligosaccharide biosynthesis to glycan transfer https://tinyurl.com/5n6t99kb

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At last! New data show that SARS-CoV-2 (Omicron in particular) preferentially infects blood group A cells. Receptor binding domain (RBD) of SARS-CoV-2 shows similarity to several galectins and binds better to ACE2 with A blood group antigen. https://tinyurl.com/47w7rumu

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Golgi satellites (GS) are capable of complex glycosylation and polysialylation of neural cell adhesion molecules (NCAMs) at these organelles is essential for long-term plasticity at distal synapses https://tinyurl.com/y6s34y48

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Parkinson's disease: oligosaccharide fragment of GM1 ganglioside directly interacts with α-synuclein, inhibits its aggregation, protects neurons from α-synuclein toxicity and inflammation

https://tinyurl.com/5ba969zs

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How metal changes can affect the glycosylation and hence the glycan structures that are produced? The new field is called metalloglycobiology and you can read about it in the review https://tinyurl.com/4e8tf3zn

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Impact of C-mannose on the folding and structural stability of Thrombospondin repeats revealed by @Elisa. Great demonstration of additional essential roles of protein glycosylation #beilsteinglyco2023 #glycotime

Interesting review by Richard Cummings about glycolipids in human parasites. Unusual structures found in P. falciparum, T. gondii, Leishmania and Schistosoma spp., Brugia malayi, Onchocerca volvulus, Ascaris suum, Taenia and Echinococcus spp. Better stay away from those! https://tinyurl.com/yszp75sn

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Mucin glycans and their degradation by gut microbiota: structure of mucin and its glycans, degradation of mucin glycans and glycosaminoglyycans by microbiota, influence of mucin-degrading bacteria on human gut health and disease https://tinyurl.com/dba3wfvc

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Mucin glycans and their degradation by gut microbiota: structure of mucin and its glycans, degradation of mucin glycans and glycosaminoglyycans by microbiota, influence of mucin-degrading bacteria on human gut health and disease https://tinyurl.com/dba3wfvc

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N-glycolylneuraminic acid (Neu5Gc), a non-human sialic acid often found in cancer patients and attributed to red meat consumption, may be generated by a chemical reaction in the presence of high levels of reactive oxygen species (ROS) https://tinyurl.com/2h83fjty

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Ever wondered how often glycosylated peptides are presented by MHC class II proteins? Here is HLA-Glyco, a new computational resource containing over 3,400 HLA II N-glycopeptides from 1,049 distinct protein glycosylation sites

https://tinyurl.com/mr2n4z8k

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