Scientists have made new discoveries about how a G protein–coupled receptor coordinates cell migration in response to stimuli, which could facilitate future efforts to target this receptor or other #GPCRs in inflammation or cancer. @SciSignal #Biochemistry https://scim.ag/2gs #press

Scientists have made new discoveries about how a G protein–coupled receptor coordinates cell migration in response to stimuli, which could facilitate future efforts to target this receptor or other #GPCRs in inflammation or cancer. @SciSignal #Biochemistry https://scim.ag/2dN #press

Wichtige Entdeckung an Adhäsions-#GPCRs: Wissenschaftler:innen der #UniLeipzig machen Rezeptortrennung sichtbar und melden #Patent auf ihre Forschungsergebnisse an. https://www.uni-leipzig.de/newsdetail/artikel/rezeptorsprengung-sichtbar-gemacht-2023-03-14

In the new issue of Science Signaling, Hewitt et al. investigated the role of a conserved catalytic glutamine residue in G protein alpha-subunits, which mediates G protein inactivation. Mutations at this site in some G proteins lead to constitutive activity and oncogenesis. However, the authors found that other mutations of this residue led to multiple active state conformations, suggesting that this residue goes beyond catalysis to regulate structure and function. https://www.science.org/doi/10.1126/scisignal.abq7842 #GPCRs

@FlorianMerkle Welcome to the #CiliaFediverse Florian- we are glad your are here! :blobcatwave: #cilia #obesity #GPCRs #ciliopathies #neurons