Interesting study showing balance between bacterial & host factors determining granuloma formation and control of infection. This example being #Yersinia.
#granuloma #immunology #academia #Science #ScienceMastodon

Inflammatory monocytes promote granuloma control of Yersinia infection | Nature Microbiology

https://www.nature.com/articles/s41564-023-01338-6?utm_source=nmicrobiol_etoc&utm_medium=email&utm_campaign=toc_41564_8_4&utm_content=20230404

Fabulous resource for gaining detailed cellular & spatial understanding of immunobiology at the site of human granulomas. #sarcoid #TB #tuberculosis #tuberculosis #leprosy #granuloma #immunology #singlecell #academia #science
@ImmunityCP
https://www.cell.com/immunity/fulltext/S1074-7613(23)00024-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761323000249%3Fshowall%3Dtrue

Such a neat story about bacterial virulence factor (EsxM) contributing to bone dissemination of TB disease through actions on macrophage motility. @cellpress

Unlikely to be the whole story, and it's taking a leap from zebrafish model to extrapolate human TB disease phenotype, but v plausible that bacterial manipulation of host immunobiology can alter natural history of #TB disease. #immunology #macrophages #granuloma #bone

https://www.cell.com/cell/fulltext/S0092-8674(22)01361-7?dgcid=raven_jbs_etoc_email