Registrations are open for our #SummerSchool on Brain, Bacteria and Behaviour.

🔹10 - 14 July in beautiful Nijmegen
🔹learn about #GutBrainAxis
🔹hands-on experience in #GutMicrobiome analyses
🔹early-bird discount until 1 March

https://www.ru.nl/radboudsummerschool/courses/overview-courses-2023/2023-courses/week-4/rss04-16-brain-bacteria-behaviour-understanding/

More on the human microbiome.

Scientists expand into the world of #symbioethics by creating projects and films to raise awareness and effect change.

But please remember, other life forms, upon whom we also depend, are facing the same problems due to human behaviours. #antibiotics #gutbrainaxis #symbiosis
https://people.com/health/scientists-raise-alarm-microbiome-documentary-the-invisible-extinction/

Can gastrointestinal hormones modulate our reward responses? @cecivez and I ventured into the available data and literature to find that
🎯 ghrelin enhances reward responses within the motivational circuit! w/ @nbkroemer

Find more in our pre-print: https://www.biorxiv.org/content/10.1101/2022.11.30.518539v1

#gutbrainaxis #reward #fMRI #ghrelin #GLP1

Microbial-Derived Metabolites Induce Actin Cytoskeletal Rearrangement and Protect Blood-Brain Barrier Function https://www.cell.com/iscience/pdf/S2589-0042(22)01920-4.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004222019204%3Fshowall%3Dtrue

Nice to see the findings from our 2018 paper supported re SCFAs protecting the blood-brain barrier from LPS challenge. https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0439-y

#gutbrainaxis #microbiome

Probiotic Bifidobacteria Mitigate the Deleterious Effects of para-Cresol in a Drosophila melanogaster Toxicity Model https://journals.asm.org/doi/10.1128/msphere.00446-22

- some strains of #bifidobacteria internalized p-cresol from the extracellular environment
- #Probiotic strains to reduce levels of p-cresol sulfate in patients with chronic kidney disease in future?

#microbiome #chronickidneydisease #gutbrainaxis

#introduction

I am enjoying reading lots of different introductions over the last days so I will hop on the train as well and introduce myself! 👋

I am a PhD student at the #neuroscience for motivation, action, and desire lab working with @nbkroemer 🧠

I am broadly interested in #decisionmaking and in my PhD I am incorporating a metabolic perspective to understand how the #gutbrainaxis influences neural communication, motivation and effort. 🏋️‍♂️

Many psychiatric disorders come along with both motivational and metabolic alterations so the gut-brain perspective might help us to better understand and treat disorders like #depression #anhedonia 🎯

Mostly here for all the diverse science 💡🤩

#fmri #cognitiveneuroscience #dopamine #ghrelin

And following the #TwitterMigration Now in the right server 😉 Here comes my intro! #neuroscience #neurodon #decisionneuroscience 
Hello everyone! I’m a 4th year PhD candidate focused on decision neuroscience, noninvasive brain stimulation #nibs and the #gutbrainaxis. My research aims at clarifying the neural underpinnings of #risktakingbehavior Check out my work AlineDantas.net and connect!

Very pleased to present our latest work on the mechanisms of the gut-brain axis (https://doi.org/10.1101/2022.11.12.516113) and how the blood-brain barrier is affected in chronic kidney disease

Work was led by Sita Shah and co-authors Tobias Knausenberger, Emily Connell, Gwen Le Gall, Tom Hardy, David Randall, Kieran McCafferty, Magdi Yaqoob, Egle Solito, Michael Muller, Andrew Stachulski, Bobby Glen, David Vauzour and @BugsInYourGuts

People with CKD are at increased risk of stroke and brain blood vessel disease, but we don’t really know why. We looked at the role of the gut microbe-derived toxin p-cresol sulfate (pCS)

Using cell and mouse models we show that pCS activates the EGF receptor to cause metalloprotease release, damaging and weakening the blood-brain barrier

Importantly, we also showed that serum from patients undergoing haemodialysis for CKD damaged blood-brain barrier integrity in vitro, an effect we could block by treating with an EGF receptor inhibitor

We think this further highlights the importance of gut microbes in disease, and shows just how interlinked different organ systems are #gutkidneybrainaxis

And maybe EGF receptor inhibitors might be useful in modifying CKD stroke risk?

All of this was made possible by Alzheimer's Research UK awarding us a pilot project grant six years ago. Think we might have got a bit carried away with the amount of #gutbrainaxis work we did with it, but we are incredibly grateful!

#gutbrainaxis #BBB #CKD #cresolsulfate #kidney #gutmicrobiota #uraemia #Alzheimer'sResearchUK

Very pleased to present our latest work on the mechanisms of the gut-brain axis (https://doi.org/10.1101/2022.11.12.516113) and how the blood-brain barrier is affected in chronic kidney disease

Work was led by Sita Shah and co-authors Tobias Knausenberger, Emily Connell, Gwen Le Gall, Tom Hardy, David Randall, Kieran McCafferty, Magdi Yaqoob, Egle Solito, Michael Muller, Andrew Stachulski, Bobby Glen, David Vauzour and @BugsInYourGuts

People with CKD are at increased risk of stroke and brain blood vessel disease, but we don’t really know why. We looked at the role of the gut microbe-derived toxin p-cresol sulfate (pCS)

Using cell and mouse models we show that pCS activates the EGF receptor to cause metalloprotease release, damaging and weakening the blood-brain barrier

Importantly, we also showed that serum from patients undergoing haemodialysis for CKD damaged blood-brain barrier integrity in vitro, an effect we could block by treating with an EGF receptor inhibitor

We think this further highlights the importance of gut microbes in disease, and shows just how interlinked different organ systems are #gutkidneybrainaxis

And maybe EGF receptor inhibitors might be useful in modifying CKD stroke risk?

All of this was made possible by Alzheimer's Research UK awarding us a pilot project grant six years ago. Think we might have got a bit carried away with the amount of #gutbrainaxis work we did with it, but we are incredibly grateful!

#gutbrainaxis #BBB #CKD #cresolsulfate #kidney #gutmicrobiota #uraemia #Alzheimer'sResearchUK

Very pleased to see this out. Another huge effort from @SimonMcArthur and his research team.

Cerebrovascular damage caused by the gut microbe-derived uraemic toxin p-cresol sulfate is prevented by blockade of the epidermal growth factor receptor https://www.biorxiv.org/content/10.1101/2022.11.12.516113v1

#gutbrainaxis #microbiome #metabolome #chronickidneydisease

#Introductions
I like and care about:
#Microglia
#Microbiota
#Neurodevelopment
#Neuroimmunology
#GutBrainMicrobeAxis
#GutBrainAxis
#SciencePolicy
#RegulatoryScience
#RegulatoryPolicy
#TeaAndBiscotti
I am concerned about:
#COVID
#LongCovid

#Introductions
I like and care about:
#Microglia
#Microbiota
#Neurodevelopment
#Neuroimmunology
#GutBrainAxis
#SciencePolicy
#RegulatoryScience
#RegulatoryPolicy
#TeaAndBiscotti
I am concerned about:
#COVID
#LongCovid

Hello, and an #introduction.

I use and integrate omics data to understand how the gut microbiota influences mammalian intestinal and systemic health. I'm particularly interested in how microbially produced metabolites interact with host metabolic pathways.

My team is looking at functional and genomic aspects of gut bacteria, especially Klebsiella and Collinsella spp.

I have a soft spot for phages.

#microbiome #NAFLD #cancer #gutbrainaxis

RT @PhD_Leigh
#Microbiome research is reinforcing what we know re #HealthyEating: A #diet rich in a variety of minimally processed plants (fiber, polyphenols, etc.). Such a #PlantBased or centered diet promotes #GutHealth and #BrainHealth through the #GutBrainAxis. https://www.nature.com/articles/s41398-022-01922-0

Viruses may play an unexplored role in the gut-brain axis
#Caudovirales viruses may help fruit flies—and humans—with memory #Science #viruses #gutbrainaxis #gutmicrobiome
https://www.science.org/content/article/viruses-may-play-unexplored-role-gut-brain-axis