#Haplotigs inflate assembled #genome size and they lower coverage because each haplotig gets a portion of the true genome coverage. This give a bimodal pattern on coverage across the genome. See this publication https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-018-2485-7

See gif: https://twitter.com/jonpuritz/status/1651218353615241221?s=46

Happy to share a new publication from the @MarineEvoEcoLab describing the eastern #oyster🦪 #genome assembly.

We also describe a methodology for detecting and masking haplotigs in existing genome assemblies.

https://onlinelibrary.wiley.com/share/author/EPYJHU9F8RJ4GV6QFY4B?target=10.1111/1755-0998.13801

So what are #haplotigs? Most #genome assemblies are haploid, meaning that there is one copy of sequence for each location in the genome. Haplotigs are when allelic sequence (sequence per genome copy) are incorporated by mistake into an assembly.