The EMBO Journal · @embojournal
502 followers · 247 posts · Server sciencemastodon.com
#Microcephaly protein #DONSON is a novel factor needed for CMG #helicase assembly during vertebrate DNA #replication initiation
Yoshitami Hashimoto and colleagues
#microcephaly #donson #helicase #replication
Sterling Ericsson · @sterlingericsson
127 followers · 126 posts · Server mstdn.scienceBasic fundamental research on how DNA functions and how our cells work on a molecular level is critical to broader insights and innovations.
Delft University of Technology scientists have more precisely found how the helicase CMG unwinds DNA during replication and its full functionality in doing so with a new mechanism.
#Science #DNA #Replication #Helicase #CMG #Biology #Biochemistry #Molecular #SciComm
#Science #DNA #replication #helicase #cmg #biology #biochemistry #molecular #scicomm
The EMBO Journal · @embojournal
369 followers · 59 posts · Server sciencemastodon.com
What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?
Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage
#molecular #syntheticlethality #helicase #wrn #mismatchrepair #MMR #cancer #microsatellite #biochemcial #cruciform #dna #slx1 #slx4 #endonuclease