Last #SickleCell article for tonight.

Diet is super important, as usual.

Red Blood Cell Membrane Cholesterol May Be a Key Regulator of Sickle Cell Disease Microvascular Complications https://discovery.researcher.life/article/red-blood-cell-membrane-cholesterol-may-be-a-key-regulator-of-sickle-cell-disease-microvascular-complications/c6443f7b1b9a38408e01d66b77c1cc9e

#science #medicine #health #BloodDisorders #Blood #Heme #hematology #haematology

#BlackMastodon
@blackmastodon@a.gup.pe
@BlackMastodon@chirp.social

Well, this just threw me for a loop.

Predictors and clinical complications associated with antiphospholipid antibodies in sickle cell disease https://discovery.researcher.life/article/predictors-and-clinical-complications-associated-with-antiphospholipid-antibodies-in-sickle-cell-disease/fb1eb5a3f0f73a50befe8bf67cbcbce7

#SickleCell #BloodDisorders #AutoImmune #Heme #madness!
#science #medicine #health

#BlackMastodon
#CaribbeanMastodon
@blackmastodon@a.gup.pe
@BlackMastodon@chirp.social

#Heme biosynthesis #Angigoenesis

Roles of #EndothelialCell FLVCR1a, a heme exporter to extracellular space in
✅Developmental Angiogenesis-🐭Retina🐟ISV
✅Tumor angiogenesis
❎Vascular homeostasis

Dr. Sara Petrillo lab Angiogenesis 2023
https://link.springer.com/article/10.1007/s10456-023-09865-w

FLVCR1a deficiency-> #EndothelialCell-autonomous defects in Mitochondria, ER stress & Angiogenic behaviors

Heme accumulation triggers #Paraptosis (Organelle swelling-> Cytoplasic vacuolation)💀

Dr. Emanuela Tolosano lab Cell Death Diff 2018
https://www.nature.com/articles/s41418-017-0001-7

Other enzymes in Heme metabolism in #Angiogensis👇

Ferrochelatase is a therapeutic target for ocular neovascularization
https://www.embopress.org/doi/full/10.15252/emmm.201606561

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30391-7

Dem gibt es nichts hinzuzufügen. #spreewald #mundart #heme

Hi @DNPFred
In grad school I worked on heme proteins using #paramagnetic #NMR and #NRVS. Then I shifted to #XRayCrystallography, using #EPR #UVVis and #EDX on #crystals when a postdoc. My research group works on #NonHemeIron #enzymes, & #heme, #copper & #manganese #metalloproteins. Really interested in combining #spectroscopy on #protein #crystals to examine #structure #function relationships.

Serious heart damage is the most severe side effect of doxorubicin in cancer chemo, but the cause is not clear.
New work from Abe et al shows that

"DOX accumulated in mitochondria by intercalating into mitochondrial DNA (mtDNA), inducing ferroptosis in an mtDNA content-dependent manner. In addition, DOX disrupted heme synthesis by decreasing the abundance of 5'-aminolevulinate synthase 1 (Alas1), the rate-limiting enzyme in this process, thereby impairing iron utilization, resulting in iron overload and ferroptosis in mitochondria in cultured cardiomyocytes."

#Chemotherapy #doxorubicin #mitochondria #heme

https://www.science.org/doi/10.1126/scisignal.abn8017?utm_campaign=SciMag&utm_source=Twitter&utm_medium=ownedSocial

Referenced link: https://phys.org/news/2022-08-scientists-molecule-sops-iron-rich-heme.html
Discuss on https://discu.eu/q/https://phys.org/news/2022-08-scientists-molecule-sops-iron-rich-heme.html

Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/physorg_com/status/1557743663551508481#m

Scientists identify a plant molecule that sops up iron-rich #heme @MIT @NatureMicrobiol https://phys.org/news/2022-08-scientists-molecule-sops-iron-rich-heme.html