A network of small RNAs regulates sporulation initiation in #Clostridioides difficile

Franziska Faber and colleagues use small RNA/target interaction mapping in the enteric pathogen C. difficile to reveal the first RNA #chaperone #Hfq-dependent RNA interactome in a gram-positive #bacterium

https://www.embopress.org/doi/10.15252/embj.2022112858

Heterotypic phase separation of #Hfq is linked to its roles as an #RNA #chaperone:

#stressresponse #microbiology

https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01777-6

How does #bacterial #RNA #chaperone #Hfq regulate numerous different #mRNAs and processes?
#CryoEM by Tom Dendooven, Ben Luisi and collaborators shows assembly into distinct polymorphic #ribonucleoprotein complexes as basis

Translational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding

https://www.embopress.org/doi/10.15252/embj.2022112574