Out today in Nature Methods: our manuscript outlining improvements we've made to Genome Architecture Mapping (GAM) and comparisons between GAM and Hi-C.TLDR: We made GAM much cheaper, show that it performs better than Hi-C at detecting complex interactions and identify a class of CTCF-enhancer interactions that are poorly detected by Hi-C. Paper at https://doi.org/10.1038/s41592-023-01903-1 and the story behind the work at https://protocolsmethods.springernature.com/posts/appreciating-the-complexity-of-dna-folding #genomics #GenomeFolding #epigenetics #paper #ctcf #HiC
#genomics #genomefolding #epigenetics #paper #CTCF #hic
I am now listening to Intro by Hi-C #HiC
https://www.last.fm/music/Hi-C/_/Intro
A new variation of the #HiC method to study #3Dgenome interactions specifically for open #chromatin. "HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization" https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00098-3?
Frequent long-range #chromatin #contact from #HiC analysis in plant species. Read:
Conserved noncoding sequences correlate with distant gene contacts in Arabidopsis and Brassica
https://doi.org/10.1111/jipb.13465
The amount of deluded masses at #MetasUserbase that think, like @elonmusk thinks #Twitter is real life , that #SocialMedia is #IRL is... Astonishing.
#metasuserbase #twitter #socialmedia #irl #hic #SiC #tbd
Anchoring #3Dgenome & #chromatin contacts to #cellnucleus landmarks: Mapping #nucleolus-associated chromatin interactions using nucleolus #HiC reveals pattern of #heterochromatin interactions.
@NatureComms https://doi.org/10.1038/s41467-023-36021-1
#3dgenome #chromatin #cellnucleus #nucleolus #hic #heterochromatin
A revised, high quality, leopard gecko (Eublepharis macularius) reference genome produced using PacBio HiFi and Hi-C. Get this, 1/2 the chromosomes were assembled as contigs!!! 😮
#Gecko #Genomics #PacBio #HiC #DNA #Herpetology #Science #Biology
#biology #science #herpetology #dna #hic #pacbio #genomics #gecko
Inference of #genome 3D architecture by modeling overdispersion of #HiC data https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btac838/6967433#.Y7xWbV4S0Eg.twitter
#PLOSCompBio: HiSV: A control-free method for structural variation detection from #HiC data https://dx.plos.org/10.1371/journal.pcbi.1010760
I have clearly stated multiple times that there are certain companies in #SiliconValley that I will _NEVER_ have an account at nor will work for due to their #LackOfEthics when it comes to their #CriminalEnterprise of #BadToS & #CorporateEspionage as their focus due to #ForcedConsent and #ForcedImplants that are embedded in their #RightEye revealed easily with current technology at your #optometrist. 🔎👀🔍🧐
#siliconvalley #lackofethics #criminalenterprise #badtos #corporateespionage #forcedconsent #forcedimplants #righteye #optometrist #hic #SiC #churchcommittee2 #infosec_jcp
Annnd spin around … (even if you’re sitting still) #Hic 😁
https://m.youtube.com/watch?v=GKZgTk1dSJg
@IanMoore3000 Haven't found any academic links, but here's a bit of fun https://medium.com/lessons-from-history/the-fascinating-history-of-women-witches-and-beer-fdf7527dd8a8 (note that St Brigid was a noted ale maker, which may explain why she was consecrated a bishop instead of an abbess #hic) #NaomhBríde
#HIC #spyware #RTNDA #infosecurity
https://www.cyberscoop.com/white-house-spyware-executive-order-himes/
Nary a mention of #GammaGroup #FinFisher #FinSpy #Finsky.👀👀☣️
Noted that #GammaGroup is #UK based so will fall under the SAME terms as #NSOGroup's #Pegasus ✅️ ☣️🚫✂️😵😲👀👀🥸
#hic #spyware #RTNDA #infosecurity #gammagroup #finfisher #finspy #Finsky #uk #nsogroup #pegasus
Kicking off Day 3 and final day of #AcademicDays2022 @uga_langebio@twitter.com with the talk of my dear collaborator, scientist extraordinaire, Dr. Katarzyna "Kasia" Oktaba, telling us about Genome Topology. #HiC
@DerekL I see your Lego Star Wars Advent Calendar Day 01 and raise you my Masters of Malt advent calendar day 1.