The EMBO Journal · @embojournal
440 followers · 171 posts · Server sciencemastodon.com
#Glutamate dehydrogenase1 supports #HIF1α stability to promote #colorectal #tumorigenesis under #hypoxia
An siRNA screen identifies αKG metabolic enzyme #GDH1 as acetylation-dependent control factor for intestinal cancer progression
#glutamate #hif1α #colorectal #tumorigenesis #Hypoxia #gdh1
The EMBO Journal · @embojournal
385 followers · 72 posts · Server sciencemastodon.com
Keisuke Shigeta et al (Keio University School of Medicine) analyze #metabolic alterations leading to #chemoresistance in #urothelial cancer #bladdercancer: #IDH2 gain-of-function independent of #mutation is responsible for #HIF1α-dependent production of respective #gemcitabine and #CDDP competitors #dCTP and #NADPH
#metabolic #chemoresistance #urothelial #bladdercancer #idh2 #Mutation #hif1α #gemcitabine #cddp #dctp #nadph