This study shows that in mice loss of the core #SWI_SNF subunit #Baf155 doesn't affect gross muscle development, but leads to increased oxidative metabolism & #endurance capacity; this is mediated by Baf155 regulation of #HIF1a signaling #PLOSBiology https://plos.io/3q5jcCz

#HIF1A inhibition overcomes castration resistance of prostate tumors
By J. Terzic, M. el Maaty, D. Metzger & colleagues at IGBMC, France

#ProstateCancer

🗞️ https://doi.org/10.15252/emmm.202217209