Global histone H2B degradation regulates #insulin/#IGF signaling-mediated nutrient stress
The #ubiquitin-#proteasome system regulates #histone #H2B exchange in mammalian cells and in C. elegans during development and starvation.
#insulin #Ubiquitin #proteasome #histone #h2b
How can #replication initiator ORC load replicative #helicases in condensed chromatin?
Structural and biochemical work by Franziska Bleichert and colleagues shows how ORCA recruits ORC to certain #histone marks, and also reorganizes local #chromatin structure
https://www.embopress.org/doi/full/10.15252/embj.2023114654
#replication #helicases #histone #chromatin
Insights into the action of plant #WRKY #transcription factors: Interaction with #histone-binding #OBERON proteins forms repressive complexes keeping drought stress response genes in check
https://www.embopress.org/doi/full/10.15252/embj.2023113639
#wrky #transcription #histone #oberon
Interesting paper showing that it is possible to separate transcriptional activator and repressor functions in #Drosophila #histone deacetylase HDAC3:
https://doi.org/10.1242/dev.201548
Referenced link: https://medicalxpress.com/news/2023-06-impaired-histone-inheritance-breast-cancer.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-06-impaired-histone-inheritance-breast-cancer.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1669693324255539208#m
RT by @physorg_com: Impaired #histone inheritance accelerates breast #cancer growth and metastasis, study shows @NatureComms https://medicalxpress.com/news/2023-06-impaired-histone-inheritance-breast-cancer.html
During asymmetric #CellDivision of #Drosophila male #GermlineStemCells (GSCs), #histone H3 is preferentially inherited by the GSC, while H3.3 is not; @ChenLabJHU reveals that a single amino acid (A31/S31) underlies these inheritance patterns #PLOSBiology https://plos.io/4221cXG
#plosbiology #histone #germlinestemcells #drosophila #CellDivision
During asymmetric #CellDivision of #Drosophila male #GermlineStemCells (GSCs), #histone H3 is preferentially inherited by the GSC, while H3.3 is not; @ChenLabJHU reveals that a single amino acid (A31/S31) underlies these inheritance patterns #PLOSBiology https://plos.io/4221cXG
#plosbiology #histone #germlinestemcells #drosophila #CellDivision
During asymmetric #CellDivision of #Drosophila male #GermlineStemCells (GSCs), #histone H3 is preferentially inherited by the GSC, while H3.3 is not; @ChenLabJHU reveals that a single amino acid (A31/S31) underlies these inheritance patterns #PLOSBiology https://plos.io/4221cXG
#plosbiology #histone #germlinestemcells #drosophila #CellDivision
Linker #histone helps bridge gaps in #plant #immunity knowledge.
https://phys.org/news/2023-03-linker-histone-bridge-gaps-immunity.html
PIF7-mediated #epigenetic reprogramming promotes the #transcriptional response to shade in #Arabidopsis
Chuanwei Yang et al.find when a plant grows in shade, transcription factor PIF7 triggers the adaptive growth response by guiding H3.3 deposition via the #histone chaperone #ASF1
#epigenetic #transcriptional #arabidopsis #histone #asf1
How about some #OpenAccess #PlantScience?✅🔓⬇️
Read on to learn how Zhang et al. determined that conserved #noncoding sequences correlate with distant #gene contacts!
https://doi.org/10.1111/jipb.13465
@wileyplantsci
#Arabidopsis #Brassica #TranscriptionFactor #tf #histone
#openaccess #plantscience #noncoding #gene #arabidopsis #brassica #transcriptionfactor #tf #histone
Surprising interplay between #SMC5/6 and #transcription-regulating #PAF1 complexes in #Arabidopsis #DNAdamage response:
Shunping Yan and colleagues find them to interact and recruit E2/E3 enzymes for #histone H2B #ubiquitination at DNA double-strand breaks
https://www.embopress.org/doi/10.15252/embj.2022112756
#smc5 #transcription #paf1 #arabidopsis #dnadamage #histone #ubiquitination
Identification of a complex mechanism to read a #histone mark - Menin “reads” H3K79me2 mark in a #nucleosomal context https://www.science.org/doi/10.1126/science.adc9318
#Prokaryotes had really no respect for #eukaryotes these days #histone 😬
#histone #eukaryotes #prokaryotes
Histones-like proteins found in bacteria and function in DNA binding.
Very interesting!
#bacteria #viruses #archea #chromatin #histone
#RIP C. David Allis (1951-2023), a giant in #molecular biology #biochemistry #chromatin #histone modifications
One of my favorite piece of writting by David Allis - Very wise words : 'On being an advisor to today’s junior scientists' https://www.pnas.org/doi/10.1073/pnas.1704511114
#histone #chromatin #biochemistry #molecular #rip
Hello #ScienceMastodon Twitter refugees
#introduction I am a 🇫🇷 molecular & structural biologist working at the CNRS. I study the molecular mechanisms that control human gene expression focusing on #transcription factors & the Pol II machinery
Expect to see here a lot of info on #generegulation, #enhancers, #histone modifications & structural insights into the eukaryotic Transcription Initiation machinery. #CryoEM
I will also highlight #womeninscience to give them the visibility they deserve
#WomenInScience #CryoEM #histone #enhancers #generegulation #transcription #introduction #ScienceMastodon
Referenced link: https://phys.org/news/2022-05-linker-histone-partnership-single-stranded-dna.html
Discuss on https://discu.eu/q/https://phys.org/news/2022-05-linker-histone-partnership-single-stranded-dna.html
Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/physorg_com/status/1530231278401896449#m
Linker #histone's surprising partnership with single-stranded #DNA @RockefellerUniv @NatureSMB https://www.nature.com/articles/s41594-022-00760-4 https://phys.org/news/2022-05-linker-histone-partnership-single-stranded-dna.html