"Using zebrafish, we identified Down syndrome cell adhesion molecule like-1 (dscaml1) as an integral mediator of CRH neuron development and necessary for establishing normal stress axis function...these findings identify dscaml1 as an essential factor for stress axis development and suggest that HPA axis dysregulation may contribute to the etiology of human DSCAML1-linked neuropsychiatric disorders"
https://www.frontiersin.org/articles/10.3389/fcell.2023.1113675/full#:~:text=Using%20zebrafish%2C%20we,linked%20neuropsychiatric%20disorders

#developmentalBiology #hpaAxisDysfunction #Stresshormone

Most people don't know what it's like to have chronically fucked up #cortisol. "Don't stress out" is not only a non-answer, but irrelevant!

When my cortisol is high or crashing, I can't:

- Pay attention to the news
- Watch action movies
- Listen to music that gets me "amped"
- Exercise
- Enjoy erotica
- Work on tense scenes in my fiction
- Do basically anything that isn't calm, relaxed, slow, or *boring*.

I look forward to finally being diagnosed🤞

#addisons #cushings #HPAAxisDysfunction

Want to get back to twice daily #meditation but feeling symptomatic from #adrenalfatigue after a ridiculous October. Going to see my first #naturopath soon since I doubt my GP will be interested in doing anything. #chronicillness #hpaaxisdysfunction