Researchers discover how #mitochondria call for help when under #stress.

#signalling #proteins #misfolding #chaperonins #transcriptomics #DNAJA1 #HSP70

https://phys.org/news/2023-07-mitochondria-stress.html

How does transcellular activation of #chaperone Hsp70 occur? @HawleLab &co reveal a gut-to-muscle stress signaling pathway that activates #Hsp70 expression in muscle cells, independently of HSF-1, enhancing both stress resistance & longevity #PLOSBiology https://plos.io/3jRbUzp

How does transcellular activation of #chaperone Hsp70 occur? @HawleLab &co reveal a gut-to-muscle stress signaling pathway that activates #Hsp70 expression in muscle cells, independently of HSF-1, enhancing both stress resistance & longevity #PLOSBiology https://plos.io/3jRbUzp

How does transcellular activation of #chaperone Hsp70 occur? @HawleLab &co reveal a gut-to-muscle stress signaling pathway that activates #Hsp70 expression in muscle cells, independently of HSF-1, enhancing both stress resistance & longevity #PLOSBiology https://plos.io/3jRbUzp

For those interested, our most recent paper on #ExtracellularVesicles from uterine smooth muscle cells. More on the way!

#pregnancy #uterus #chaperones #Hsp70

https://www.publish.csiro.au/rd/RD20242

Chaperone code m&m’s ready to give out at #CellBio2022 😀 #chaperone #hsp70 #science

Proteomic studies have uncovered a huge number of post-translational modifications on chaperones (over 100!). We like to think of these #PTMs like keys on a piano. Stresses to cells like heat or DNA damage cause a unique combination of keys (PTMs) to be played making a song (unique #Hsp70 function). We are trying to match stresses to each PTM and work out the function of this "chaperone code" in normal and cancerous cells. For more, please see: https://www.sciencedirect.com/science/article/pii/S0021925817501076?via%3Dihub