Subset of neurons in #hypothalamus increases appetite & decreases #thermogenesis. @JongSohn &co show that ion channel GIRK2 functions in hypothalamic NPY/AgRP neurons to increase energy expenditure in mice and may control body weight @kaistpr #PLOSBiology https://plos.io/3qGa8Ev

Where do phobias come from? | BBC Ideas

https://www.youtube.com/watch?v=zmPzvWoE5Xk

#phobia #psychology #amydgala #hippocampus #hypothalamus #fear

A molecular network map of orexin-orexin receptor signaling system. https://doi.org/10.1007/s12079-022-00700-3 #Orexin #Pathvisio #Sleep #Feeding #Hypothalamus

Fate-mapping, combined with gain- and loss-of-function approaches, reveal the role of BMP signalling in the spatio-temporal development of the tuberal #hypothalamus, a critically important brain region. https://elifesciences.org/articles/83133?utm_source=mastodon&utm_medium=social&utm_campaign=organic #Neuroscience #DevelopmentalBiology

The #hypothalamus is a #brain region linked to many innate #survival behaviors like mating, hunting, and the fight-or-flight response. #Scientists have long believed that #neurons in the hypothalamus are functionally specific
#Neuroscience #sflorg
https://www.sflorg.com/2023/01/ns01052301.html

@ReimanSaara it's probably not attractive, but what we call #hypothalamus #abduction (or there was a similar word I forgot)
Human brains get easily distracted by fear related news

Happy to share our new article, which has been in the making for a veeery long time!

https://insight.jci.org/articles/view/165763

In this study we looked at the control of the entrance of #ghrelin in the #brain

Ghrelin is a #hormone produced by the stomach, which induces hunger. In order to do so, ghrelin needs to enter the brain, to reach neurons in the arcuate nucleus of the #hypothalamus, a region of the brain important for many #endocrine responses.

Here, we explore the role of cells lining the capillaries (such as #perycytes ) at the median eminence, which is on of the "doors" of the brain, where molecules from the periphery are allowed to get in.

We used a mouse model where pericytes can be electrically excited via #optogenetics to study the dynamics of ghrelin entrance in the brain. When we excited pericytes, there was a slow-down of blood flow at the median eminence, resulting in slower entrance of ghrelin, lower and delayed food intake in response to ghrelin injection.

This shows pericytes as a potential therapeutical target for metabolic diseases.

I want a #Hypothalamus for #Christmas
Only a hypothalamus will do
Don't want a #Doll - no #Dinky #Tinker #Toy
I want a hypothalamus to #Play with and enjoy
I want a hypothalamus for Christmas
I don't think #SantaClaus will #Mind - do you?

#Mindless #Dry #Humor

klingt sehr spannend. "We evaluated the effect of Kdm6a-KD on Ngn3 expression, a bHLH transcription factor regulating neuronal sub-specification in #hypothalamus. Kdm6a-KD decreased Ngn3 expression in females but not in males, abolishing basal sex differences." (Quelle: "Epigenetic modifier Kdm6a/Utx controls the specification of hypothalamic #neuronal subtypes in a sex-dependent manner" DOI DOI 10.3389/fcell.2022.937875 - Oktober 2022. #Geschlecht #Gehirn #neuronal #verankert #Brainsex

#hypothalamus and #aging:

Hajdarovic, Yu & Webb highlight single-cell studies interrogating cell types of the mouse hypothalamus, and suggest ways in which single-cell ‘omics technologies can be used to further understand the aging hypothalamus and its role in longevity. #neuroscience

https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(22)00192-8

RT @ChantalBritt@twitter.com

Great @VirusesImmunity@twitter.com talk about #LongCovid:
#autoimmunity most likely not driver
focus on tissue damage, viral reservoirs, dysbiosis & #EBV #VZV reactivation
cortisol levels lower (defect in #hypothalamus and/or #pituitary?)
more antibodies, less functional to neutralise SARS2

🐦🔗: https://twitter.com/ChantalBritt/status/1593618574807031811