#IDMastodon #PedsID @panhammarstrom @casanova_lab There is growing evidence to suggest that severe disease in children infected with common viruses or #SARSCoV2 that are benign in other children can result from inborn errors of immunity or their phenocopies. #COVID19 can lead to acute #hypoxemic in children with inborn errors of type I ( IFN) immunity or #Autoantibodies against IFNs.
📌 https://onlinelibrary.wiley.com/doi/epdf/10.1111/joim.13628
📌 https://pubmed.ncbi.nlm.nih.gov/36906905/

#IDMastodon #Immmunology #CellImmunity #InnateImmunity @JEM Inherited MyD88 & IRAK-4 deficiencies are predisposed to #hypoxemic #COVID19 . The patients’ susceptibility to #SarsCoV2 can be attributed to impaired TLR7-dependent type I IFN production by pDCs, which do not sense #SARSCoV2 correctly
📌 https://rupress.org/jem/article/220/5/e20220170/213920/Humans-with-inherited-MyD88-and-IRAK-4
📌 https://rupress.org/jem/issue