🙌 The "Outstanding Paper Prize" by @Dev_journal goes to a study by our researchers @bulutkarslioglu, @nata__93, and former MPIMG member @jvveenvliet now at @mpicbg. It's a great story about #embryology, #hypoxia, & #gastruloids. Congratulations!

🔗 https://www.molgen.mpg.de/4615582/

@mckra1g "Put your own oxygen mask on first." Well, a big part of that is because it's dang hard to help anyone when you're suffering from hypoxia yourself, but you CAN help someone who is suffering from hypoxia if you aren't. 🙂 🛬 (Also #hypoxia is insidious, in that it's often quite difficult to tell by yourself that you are suffering from it in time to do much of anything about it.)

Snoring And Sleep Apnea May Lead to Young Athletes’ Sudden Death: Best Of: 0319
Stocky, young athletes often experience disordered sleep snd breathing patterns that predispose to heart attack and sudden death. #Snoring #apnea #hypoxia #sleepdisorderedbreathing #teens #athletes
https://youtu.be/aDxNp5d4ulY

Epigenetics #PulmonaryArterialHypertension

JMJD1C a histone demethylase
⏫p-STAT3->
⏫#Glycolysis HK2/PGK1/LDHA->
⏫PA #SmoothMuscleCell Proliferation

Serum Lactate⏬by AAV2-shJMJD1C in🐭#Hypoxia-PAH
Local effect on #EndMT?

Dr H Zhao lab Cell Death Discovery 2023
https://www.nature.com/articles/s41420-023-01390-5

Ocean currents, agricultural runoff, landscape, and a variety of other local and regional conditions mean that our oceans have just as diverse an array of habitats as dry land, if not more. Consequently, while we know that, overall oceanic oxygen levels are decreasing, that doesn’t actually tell us how that is progressing in different ecosystems. For that, we actually need to pay people to go check. Fortunately, while I think we don’t spend enough on that, we do spend quite a bit on it, as a species, and so we have some new information about how the ocean’s deoxygenation is progressing in what may be the single most “charismatic” set of oceanic ecosystems – coral reefs.

#GlobalWarming #ClimateChange #ClimateCrisis #Hypoxia #Anoxia #DeadZone #Coral #Reef

https://freethoughtblogs.com/oceanoxia/2023/03/17/coral-reefs-are-losing-oxygen-as-the-planet-warms-and-we-should-do-socialism-about-it/

Ocean currents, agricultural runoff, landscape, and a variety of other local and regional conditions mean that our oceans have just as diverse an array of habitats as dry land, if not more. Consequently, while we know that, overall oceanic oxygen levels are decreasing, that doesn’t actually tell us how that is progressing in different ecosystems. For that, we actually need to pay people to go check. Fortunately, while I think we don’t spend enough on that, we do spend quite a bit on it, as a species, and so we have some new information about how the ocean’s deoxygenation is progressing in what may be the single most “charismatic” set of oceanic ecosystems – coral reefs.

#GlobalWarming #ClimateChange #ClimateCrisis #Hypoxia #Anoxia #DeadZone #Coral #Reef

https://freethoughtblogs.com/oceanoxia/2023/03/17/coral-reefs-are-losing-oxygen-as-the-planet-warms-and-we-should-do-socialism-about-it/

@KnightADRC

from original article:
"fructose is also produced in the body via the polyol pathway, in which glucose is converted to fructose"
https://doi.org/10.1016/j.ajcnut.2023.01.002
#hypoxia #OsmoticStress #polyol

AAAS: "Breathless Oceans" Climate change is leaching oxygen from the ocean by warming surface waters, increasing metabolic rates of fish + crabs, + boosting stratification of warmer surface water, preventing mixing. In higher latitudes, meltwater from ice + snow creates freshwater layers on top of saltwater, also interfering with mixing by waves + wind. "Scientists for yrs have documented oxygen-starved dead zones in places like the Gulf of Mexico and the Baltic Sea." In 2017 a paper in Nature reported the global ocean had 'already lost some 2% of their oxygen since 1960, roughly double what climate models predicted.' Andreas Oschlies, a biogeochemist at the GEOMAR Helmholtz Centre for Ocean Research Kiel notes if the trend continues, it could mean a potential loss of 20% by 2100. Regional variations count. Off the Oregon coast, crabbers in 2002 began pulling up traps full of suffocated crabs, an area 'fed by a deep, oxygen-depleted current from the North Pacific Ocean that wells up near the coast.' Low oxygen levels are routine, but in 2002 scientists found oxygen levels had fallen by 65%. Even if falling oxygen doesn’t kill marine animals, it can interfere with fish hormones crucial to reproduction, stunt growth in young fish, weaken immune systems, and even strike animals blind. Deoxygenation may ultimately be a greater driver of extinctions than acidification + marine heat waves. Time to get serious about climate weirding. #hypoxia #climatechange

#Hypoxia in #rivers and #streams is generally much more prevalent across the globe than previously thought. Hypoxia is low or depleted #oxygen levels in surface #waters that can be harmful to #aquatic species
#EarthScience #Environmental #sflorg
https://www.sflorg.com/2023/01/en01242303.html

Partial #EndMT,⏫by #Hypoxia-induced CD45, as a major cellular source for neointima formation

50% ECs in ligated artery are CD45+

CD45 is required to maintain this Partial status
Amazing!🤩

Dr. Yoshito Yamashiro & Yoshito Yamashiro lab #CardiovascRes 2022
https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvac190/6942105

How CD45 titrates the extent of mesenchymalization of #EndothelialCell?

CD45 stabilizes VE-cad junction via fortifying integrin α11-SHARPIN complex

Very interesting data on Biomechanics of #EndMT 😋

What (beyond CD45) control partial-to-complete EndMT transition?🤓

Very happy the YT algorithm let me know about Real Science channel's 'Insane Biology' series. This recent one on human physiology has me looking up the original papers.

https://youtu.be/cI6aFO8svqA

Physiological and Genetic Adaptations to Diving in Sea Nomads [Bajau people]
https://doi.org/10.1016/j.cell.2018.03.054

#science #biology #physiology #diving #hypoxia

New study on the effects of P limitation on hypoxia development in the East China Sea out today: https://bg.copernicus.org/articles/19/5893/2022/

#hypoxia #eastchinasea #Plimitation #oceanmodel #egujournals

..like myself were often given heaps of unnecessary (and untolerable) anti anxiety meds and told collapsing and other symptoms of orthostatic intolerance including light-headedness were just down to vertigo.

#MECFS #pwME #OI #LongCovid
#PoTS #hypoxia #dysautonomia

We suddenly had a story. Rapha Ardicoglu joined as a PhD student and our teams started cranking out data.

#Hypoxia and angiogenic growth factors trigger Apold1.

Also in vitro, Apold1 knockout or knockdown in ECs obliterates proliferation & sprouting - a cell-intrinsic deficit!

Researchers reveal role of #methyltransferase #SMYD3 in #hypoxia tolerance.

https://phys.org/news/2022-11-reveal-role-methyltransferase-smyd3-hypoxia.html

Who? (Who Needs Oxygen Anyway!)
#hypoxia #skydiving

Similar? Wait is that a dog wearing a mask?
#news #COVID19 #mask #hypoxia #Pfizer #FDA #Biden

Listen closely to what Phil Heath says, most of you don't know don't follow the bodybuilding world, but listen closely to what he said about Mask. And listen to Ricardo Aguilar about standing up for our next generation kids.
#news #masks #vaccines #valuetainment #olympia #philheath #hypoxia #fear #kids #yesterdaynews #pbdpodcasts