New Il-2 Sturmovik video:

Slowly developing my (very rudimentary) ground attack skills.

Low level attack in an Ilyushin Il-2 'Sturmovik' 1941 (1 series) armed with RS-82 rockets on German armour approaching Moscow.

Got a bit close to the ground, but happy overall. Definitely need more strike practice, though!

#Gameplay #Aviation #WW2 #EasternFront #GroundAttack #Strike #Il2 #Tanks #Rockets

https://youtu.be/HaGd2xB_63Y

Molecular and cognitive signatures of #ageing partially restored through synthetic delivery of #IL2 to the brain

By M.G. Holt, L. Yshii, A. Liston & colleagues at VIB-KU Leuven Center for Brain & Disease Research

👉 https://doi.org/10.15252/emmm.202216805

'As of yet, none of the improved IL-2-based compounds gained regulatory approval for the treatment of cancer or autoimmune diseases. Three compounds treating cancer have entered phase 3 trials with two studies still ongoing. NKTR-214 is the only compound that has completed phase 3 studies.'

#Immunology #Immunotherapy #IL2 #Preprint

https://www.medrxiv.org/content/10.1101/2022.12.02.22283042v1

"A close examination of the IL-2–IL-2Rα binding interface reveals a putative “pH Switch” consisting of the interaction between Arg38 in IL-2 and His120 in IL-2Rα (Fig. 2F). We hypothesized that, at the low pH in the TME, His120 would become protonated, resulting in release of IL-2 from IL-2Rα and therefore lack of signaling."

#Immunology #Cytokine #Immunotherapy #IL2

https://www.science.org/doi/10.1126/sciimmunol.ade5686

RT @RoychoudhuriLab@twitter.com

Excited to see this collaboration with @at_Mitralab@twitter.com @LabMoraga@twitter.com finally out! #IL2 is inactivated by acidic pH rendering it poorly effective within acidified tumors. We engineered a pH-resistant IL-2 #mutein selectively active at #acidic #pH. https://www.science.org/doi/10.1126/sciimmunol.ade5686

🐦🔗: https://twitter.com/RoychoudhuriLab/status/1598961234400858112

RT @KevinKXHe@twitter.com

Impressive talk by Prof. Adrian Liston (@LabListon@twitter.com) from @BabrahamInst@twitter.com @Cambridge_Uni@twitter.com on boosting brain #Treg in traumatic brain injury (#TBI) and neurodegeneration.

#IL2 #neuroimmunology #ASI2022MEL @ASImmunology@twitter.com

🐦🔗: https://twitter.com/KevinKXHe/status/1597775573115228162