In #Science (@sciencemagazine) this week, the Hanahan lab shows that the #RNA-binding protein #FMRP enables #tumors to evade being attacked by #CD8TCells. It does so by both suppressing #CCL17 & promoting #Tregs via #IL33 & #M2 #macrophages via #PROS1 & #ExtracellularVesicles!
#rbp #cancerimmunology #extracellularvesicles #pros1 #macrophages #M2 #il33 #tregs #ccl17 #cd8tcells #tumors #FMRP #RNA #Science