Novavax & Moderna XBB.1.5 Fall Booster Performance

This thread provides some data from preprint studies about how well the updated #Novavax and #Moderna #booster #vaccine performs on recent #variants including some details on #immune #imprinting 🧵 1/

The one page easier to share version of this thread can be found at: https://threadreaderapp.com/thread/1701396947871916279?refresh=1694514513

https://homeopathicremedies.review/immune-system-boosters/ Your Immune System is your lifeline against all the pathogens you encounter in your life. Natural antiviral herbs, minerals and supplements are your best protection against bacterial, fungal and viral infections like the Coronavirus covid-19 and created variants like LongCovid HIV bioweapons that has been unleashed against us. They are made to attack your lungs and immune system so you have to go to a hospital and get lethal drugs like Remdesivir which usually leads to being on a respirator. That usually ends up as being fatal! It is critical that you protect your lungs and respiratory system. Don't fear it but do Protect yourself. #covid -19 #immune #immunity #jab #vaccines

This is amazing #tech.

“They have shown for the first time that #kidney #cells, housed in an implantable device called a #bioreactor, can survive inside the body of a pig and mimic several important #kidney functions. The device can work quietly in the background, like a pacemaker, and does not trigger the recipient’s #immune system to go on the attack.” https://www.ucsf.edu/news/2023/08/426056/can-artificial-kidney-finally-free-patients-dialysis

Last talk of the #CSSingleCells23 conference:
Karin Pelka, Gladstone/UCSF
https://gladstone.org/people/karin-pelka

Spatially organized #immune hubs in #colon #cancer
#ColonCancer
#scRNAseq

https://pubmed.ncbi.nlm.nih.gov/34450029/

Then: predict cellular interaction networks via correlations of gene program activities across #tumors

anti-tumor hubs in tumors, ISGs including CXCR3 ligands, differs between tumor types (MMR+ or -)

have data from clinical trial (biopsies before and after treatment)
https://pubmed.ncbi.nlm.nih.gov/36702949/

1/2

Next is Melanie Samuel from BCM
https://thesamuellab.org/

Molecular regulation of #immune cell #plasticity and function in the #brain

"Our brain is the ultimate time machine" 🙂

How to target #synapses (for intervention) while preserving them (to avoid "turning back the clock"

Possibility that #microglia could be harnessed

partnered with IMPC (impc.org) to find microglia regulators in retina
one cool hit: SIRPα
it's NOT involved in #phagocytosis... surprise

#CSSingleCells23

1/2

Now Aki Minoda, Radboud University, The Netherlands
https://www.ru.nl/en/departments/radboud-institute-for-molecular-life-sciences-fnwi-deel/cell-biology
talking about
the Mukin Mouse Ageing Atlas
(mukin means #germ-free in Japanese)

#SingleCell from tissues sampled at 2 and 19 months in mice, then #omics including #lipidomics

Looking at influence of #microbiota on changes in #aging e.g. expansion of #immune cell types, aka #inflammaging

#CSSingleCells23

My null model of #infection is independent probabilities per propagule, and I hadn't seen reason to change it. This paper claims elevated #SarsCoV2 infection risk for higher doses for non-naive hosts. Perhaps slower #exposure gives mismatched #immune response a fighting chance?

@ProfCharlesHaas, would love your take on this

"A study from Cornell shows that the #SARS-CoV-2 virus can reprogram genes in Hematopoietic Stem and Progenitor Cells (HSPC) in both humans and mice. SARS-CoV-2 viral infection gene changes can activate #inflammation and affect #immune function for at least a year after COVID infection. Reprogramed monocytes were found to release cytokines and then migrate to the brain and the lung. IL-6 was implicated in this process"

3/n

https://drruth.substack.com/p/covid-news-and-more-82623?utm_medium=email

Some German cites (those that di testing) reporting an 14 day incidence of 1303 per 100’000 🙄

It’s summer. That doesn’t looks like seasonal and that doesn’t sounds very healthy or normal at all.

Dear journalists, the usual experts you interviewed the last three years are crap. Please do your job and find some new ones that are able to explain this.

https://www.unimedizin-mainz.de/SentiSurv-RLP/dashboard/index.html

#COVID19 #newnormal #immune #journalism

https://holistichealth.one/5g-dangers/ 5G towers are being expanded and now coming to within yards of your home, school or office. They can wipe out your immune system (so you catch every virus going around, like the created and patented covid-19 and variants), destroys DNA, cause cancer and fries your brain the closer you are to the signal (keep that cell phone away from your head and use protection! When your cells are weakened by 5G pathogens (particularly the Covid-19 coronaviruses) will wreak havoc in your body, that's what they've been engineered to do. Learn how to protect your home and family's health from these harmful frequencies. #EMF #5G #covid-19 #immune #cancer

https://herbalremedies.one/immune-system-boosting-herbs/ Your immune system not vaccines or chemicals keep you alive and healthy. Vax ingredients deplete your immune system and can lead to autoimmune issues. Natural immune boosting herbs keep your immune system in proper balance so it protects you from harmful infection symptoms from any planned or unplanned pathogen like covid-19, monkeypox or even the common flu or cold. Building natural immunity is far better than taking toxic vaccines or antibiotics. It can save you from antibiotic resistant bugs and keep you and your family healthy, no matter what epidemic or plandemic is going around! Be awake not woke! #immunity #immunesystem #immune #monkeypox #covid -19

Severe #COVID19 may lead to long-term innate #immune system changes

> These findings suggest that #SARSCoV2 can cause changes in gene expression that ultimately boost the production of #inflammatory #cytokines and one type of those cytokines perpetuates the process by inducing these changes in stem cells even after the illness is over.

https://www.nih.gov/news-events/news-releases/severe-covid-19-may-lead-long-term-innate-immune-system-changes

Epigenetic memory of #coronavirus infection in innate immune cells and their progenitors

https://www.cell.com/cell/fulltext/S0092-8674(23)00796-1

#Sars2 #covid19

Turns out the #Thymus, which doctors sometimes remove during heart surgeries - simply because it's in their way - plays an important role in #immune response - especially against #cancer

https://news.harvard.edu/gazette/story/2023/08/turns-out-lowly-thymus-may-be-saving-your-life/

@chfloudas how intersting. The #immune system ability to modulate responses never ceases to amaze. Though perhaps shouldn't be so surprised given the number of possible combinations of cytokine signalling!

Check out our lab's #newpaper in @cellpress Cell:
We found that the skull is special - its marrow is a special immunologic niche. Skull #Immune #cells can move to the meninges via skull-meninges connections, which we found both in mice and humans with #tissueclearing and #lightsheet #microscopy.
We also bring #proteomics and #PETimaging to the mix!

Paper: https://doi.org/10.1016/j.cell.2023.07.009

Explainer thread:
https://bird.makeup/users/erturklab/statuses/1689293936185991169

#Chemical companies’ #PFAS payouts are huge – but the problem is even bigger

#3M, #DuPont, #Chemours and #Corteva have agreed settlement in the billions for #polluting drinking #water with ‘forever chemicals’

by Tom Perkins, Aug 3, 2023

"“When the chemical giant 3M agreed in early June to pay up to $12.5bn to settle a lawsuit over PFAS contamination in water systems across the nation, it was hailed by attorneys as 'the largest drinking water settlement in American history', and viewed as a significant win for the public in the battle against toxic 'forever chemicals'.

“A second June settlement with the PFAS manufacturers DuPont, Chemours and Corteva tallied a hefty $1.1bn. But while the sums are impressive on their face, they represent just a fraction of the estimated $400bn some estimate will be needed to clean and protect the nation’s drinking water. Orange county, California, alone put the cost of cleaning its system at $1bn.

“‘While over a billion dollars is real money, it is a virtual drop in the bucket of potential utility costs to monitor, remove and dispose of these contaminants in accordance with anticipated federal regulations,' the American Municipal Water Association trade group said in a statement.

“Moreover, the two settlements include just over 6,000 water systems nationwide. Utilities that were not part of the suits but have PFAS in their systems can claim some of the settlement money, or they can sue the chemical manufacturers on their own.

“That means the settlements only represent the first wave of utility lawsuits to hit #ChemicalManufacturers, legal observers say. Because PFAS are so widely used and the scale of their harm is so great, chemical makers will get hit from a range of legal angles, and some suspect the industry’s final bill could exceed the $200bn paid by #BigTobacco in the 1990s.

“The number will be 'very large', said Kevin McKie, an attorney with the Environmental Litigation Group who represented a water management company in the 3M case. Though the 3M settlement does not cover all the nation’s costs, it is a strong start, he added.

“‘A good settlement is one where both sides walk away a bit frustrated’ is the old saying,' McKie said. 'Of course I would have liked a bit more money but I do believe they got as much as they could at this time, and there’s a lot more to go.'

“PFAS are a class of about 15,000 compounds used to make products across dozens of industries resistant to water, stains and heat. They are called 'forever chemicals' because they do not naturally break down, and are linked to #cancer, #KidneyDisease, #liver conditions, #immune disorders, #BirthDefects and other health problems.

“The chemicals are thought to be contaminating drinking water for over 200 million Americans. Tens of thousands of contaminated #PrivateWells are not included in the settlement. The chemicals are also widely used in thousands of consumer products from #DentalFloss to #cookware to #clothing, and have been found to #contaminate #food, #soil and #air.

“PFAS constantly cycle and accumulate throughout the environment, and removing them from water is costly. The highly mobile chemicals can slip through most utilities’ filtration systems. Granular activated carbon and reverse osmosis are considered the best options.

“Leaders in Stuart, Florida, which was the bellwether case in the 3M settlement, chose to take what they could get without further litigation. Bellwethers are cases that represent all the other plaintiffs in a multi-district lawsuit. Stuart estimated damages at up to $120m, and the city acknowledged the settlement would fall short.

“‘I don’t think we’ll ever get close to that much net to the city, so I think there is no making us whole,' Stuart’s city manager told the New York Times.

“Among those utilities going at it alone is the Cape Fear Public Utility Authority (CFPUA) near Wilmington, North Carolina, which sits on the #CapeFear River about 75 miles downstream from a Chemours PFAS manufacturing plant. It cost the utility about $46m to develop a granular activated carbon system to remove PFAS, and officials estimate an additional $5m in annual operational costs.

“The utility declined to comment, citing ongoing litigation, but in a late June op-ed, the CFPUA director Kenneth Waldrop explained the motivation for not joining the settlements: 'The information currently available suggests that the proposed settlement, when divided among thousands of other utilities with similar needs, would be insufficient to meet the needs of our community.'

“The utility has a 'strong case' against Chemours which has the reserves to cover the full cost, Waldrop added. There is generally support for that approach among Wilmington-area residents, said Emily Donovan, a public health advocate who lives in the region.

“‘This is not our fault, but it has been made our problem, and the community mostly understands what’s going on,' she said.

“The settlements also drew unlikely opponents in 22 state attorneys general who urged the judge to reject the 3M settlement because it 'does not adequately account for the pernicious damage that 3M has done in so many of our communities', said the California attorney general, Rob Bonta.

“Beyond water utility settlements, chemical makers face personal injury suits. Most US states will also probably sue over #contamination of #lakes, #rivers and other #NaturalResources #Minnesota alone found eliminating PFAS contamination from its wastewater could run to $28bn.

“Local water systems that are not made whole will need help from the federal government, which 'basically abandoned public water infrastructure a long time ago', said Oday Salim, director of the Environmental Law and Sustainability Clinic at the University of Michigan.

“‘Any amount of money that gets shifted to the victims is helpful,' he added.
“The government could implement an excise tax on PFAS to help cover costs, McKie said, and he noted the chemical manufacturers are taking a significant hit. By some estimates, 3M’s PFAS liabilities may soar to as much as $30bn as claims roll in.
“‘That’s a pretty big chunk of the total size of their corporation,' McKie said."

https://www.theguardian.com/environment/2023/aug/03/chemical-companies-pfas-payouts-forever-chemicals

#EPA #EPAFail #PFOS #WaterIsLife #ToxicWaste #ChemicalIndustries #ForeverChemicals

@danai @academicchatter @sfmatheson

New in @sciencemagazine (🐦): our #immune system doesn't just shape our #microbiome, our microbiome shapes our immune system. Our study supports the idea that specific host immune genes have been tailored/selected to deal with specific microbes.

1/n🧵

https://www.science.org/doi/10.1126/science.adg5725

Art: Diego Galagovsky (@sciflies)

I think it's also important to note that a lot of issues that we didn't think were related to the gut we are now finding directly connected to the microbiome and that these issues likely extend much further than conditions like #IBS or #SIBO.

Metabolic conditions ie #T2D, #inflmmation, #immune function, and #inflammation are all included in this.

Introduction: Cheesehead who toots for democracy, proactive responses to coming climate crisis and some jokes, but mostly to engage with health care providers and scientists interested in #immune recovery after HIV/ cancer and just the stress of life as all our thymus's slowly involute

Very exciting that this paper is out now in #cancercell: https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00216-7

In brief: we show that in esophageal #adenocarcinoma #checkpoint #therapy success is predicted by an independent combination of mutation burden and the amount of #monocytes in the tumour pre-treatment (as measured by RNAseq). Very exciting link between #myeloid cells and #immune response to #cancer!