Check out some #CoolScienceImages from a Nature Communications study on #fluorescencefriday. Nikolos et al. showed that an iDAMP blockade approach synergizes with #chemotherapy and sensitizes #bladdercancer to #immunotherapy in #preclinicalmodels.

https://www.nature.com/articles/s41467-022-29026-9

Music: Baby Don’t Hurt Me by David Guerra, Anne-Marie, & Coi Leray

#CancerMoonshot
#CancerMoonshotSeminar
#CMSSChan
#cancerresearch
#ImmuneCheckpointBlockade

Excited to share our work of the of the last 5 years. https://www.biorxiv.org/content/10.1101/2023.01.06.523012v1. We found that in response to the ISR, the primate-specific #lncRNA LISR customises the #ribosomes to drive translation of an immune suppressive signature. The signature includes #neoantigens translated from lncRNAs, the #immunecheckpoint receptor PDL1 and the #glycocalyx. LISR KD restores sensitivity to #immunecheckpointblockade in #melanoma and possibly in other cancers.

Cool paper dissecting the mechanism of action of #immunecheckpointblockade, anti-CTLA-4, and showing the important role of #myeloidcells #macrophages

"Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through FcγR engagement and type I interferon signaling"

https://www.nature.com/articles/s43018-022-00447-1

#Senescence #ImmuneSurveillance
Next-gen #Senolytic

#ImmuneCheckpointBlockade activates CD8+ T cytotoxicity against (inflammed🔥) PD-L1+ senescent cells->
⏬adverse phenotypes in🐭#Aging+#NASH

Dr. Yoshikazu Johmura & Makoto Nakanishi labs Nature 2022
https://www.nature.com/articles/s41586-022-05388-4

Referenced link: https://medicalxpress.com/news/2022-07-tumors-specific-genetic-mutations-response.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2022-07-tumors-specific-genetic-mutations-response.html

Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/medical_xpress/status/1547201191452590081#m

RT by @physorg_com: Tumors with specific #geneticmutations show response to #immunecheckpointblockade therapy @NatureGenet https://www.nature.com/articles/s41588-022-01108-w https://medicalxpress.com/news/2022-07-tumors-specific-genetic-mutations-response.html