#IDMastodon @ISID_org An unusual presentation of invasive Fusarium #aortitis in an immunocompromised patient Recentl ,invasive disseminated fusariosis Cases have been increasingly reported in hematological patients with #neutropenia & #Tcell #immunodeficiency . Despite the recent advances in #antifungal development, the disease has a poor prognosis with high mortality, given the limited treatment options due to frequent multiple intrinsic resistances.

New primary atopic disorder / monogenic gastrointestinal disease!
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RT @JExpMed
International collaborative team discover that gain-of-function variants in STAT6 explain some cases of severe, early-onset allergic disease: https://bit.ly/3J81uEa
@TurveyLab @casanova_lab @dan_leung_ @BeziatV @IsabelleMeyts
#allergies #immunodeficiency
https://twitter.com/JExpMed/status/1633550425218764801

RT @HarrySpoelstra
Important study:

Patients with COVID-19 have reduced thymic T-cell output, and disease severity is inversely correlated with thymic function.

➡️More proof for #Immunodeficiency, maybe even for the longterm (#Covid19 related auto-immune diseases)

https://www.sciencedirect.com/science/article/pii/S0091674923001471

“Take-home message:
- Many studies have reported changes in the molecules and cells of our #immune system following a #COVID19 infection, but even dramatic changes do not necessarily imply a loss of function
- The clinical evidence we have so far does not show that a mild COVID-19 infection causes a significant #immunodeficiency”

https://www.mcgill.ca/oss/article/covid-19/does-covid-19-mess-immune-system

A newly discovered #immunodeficiency in children should expand the catalogue documenting such diagnostic genes. Researchers from #mdcBerlin, ECRC and @ChariteBerlin identified a mutation in a transcription factor that plays a key role in the #ImmuneSystem: https://www.mdc-berlin.de/news/press/inborn-immunodeficiency-discovered-and-explained

RT @unbiasedscipod@twitter.com

There is a misconception circulating that COVID-19 causes immunodeficiency. T cells are not being “wiped out." Yes, there is some evidence that some people have temporary immune system changes/perturbations after SARS-CoV-2 infection, but that is not the same as #immunodeficiency

🐦🔗: https://twitter.com/unbiasedscipod/status/1614401002400059395

Recently Published!

Immunodeficiency, Leukemia, and Lymphoma

https://link.springer.com/chapter/10.1007/16833_2022_82

#Cancer #CancerResearch #Immunodeficiency #Immunology

Lentiviral Gene Therapy for Artemis-Deficient SCID 😵
#immunology #ImmunologyMastodon #immunodeficiency #genetherapy https://www.nejm.org/doi/full/10.1056/NEJMoa2206575?query=TOC&ssotoken=U2FsdGVkX1%2FHRBcFgjORF00I2MUyqu10WliErDNHp0C5LVkEd2Bz204VoiDBv7BqiNzLbfIIB52zQ2GI6mzY3lt0mnroAel1A25DNPeYqprqPt2lF%2BOBrhDDitT%2BMLFglpMSpdh89Zxed5IaIHsyFJW42Nc%2F%2BGpYBu6hlJYccd23jd2jVOIIz8iF69uQ58SmcaK9nC9YzDQoX9%2FzGDiqQw%3D%3D&cid=NEJM%20eToc,%20December%2022,%202022%20DM1802081_NEJM_Non_Subscriber&bid=1326909370

Ignore the title and reference to ivermectin. This article is not primarily political, but the title reflects how the pandemic in general is political. Don't let that turn you off.

The article explains our situation really well, including why so many hospitals are filling with sick kids. It's important that people understand the issues discussed in this post.

#immunodeficiency #ImmuneDysfunction #immunityDebt #LongCovid #postCOVID #OrganDamage #RSV #Strep #SickKids

https://thegauntlet.substack.com/p/with-immunity-debt-democrats-are

When you are feeling well and return to activities, #BeKind and #WearAMask for a few weeks after infection to prevent spread to friends, family member, and co workers.

This also helps to protect you, since after infections your body might not be able to fight off new infections as easily. #immunodeficiency
3/

This is a fabulous post on why people are sicker this year than in years past.

#Flu #RSV #Influenza #Fever #Cough

Hint: it's not #ImmunityDebt

#immunodeficiency #CovidIsNotOver

https://jessicawildfire.substack.com/p/it-was-never-mild-and-we-dont-have

@tootiatricians @jessicawildfire

@profcelentyx @cellpress Interesting... I get #IgG infusions for #immunodeficiency. Some batches cause severe knee joint pain-worse than my baseline and the joints make horrible noises. Now I'm wondering if the IgG is inflammatory sometimes? I've only started IgG a year ago so I don't know what it was like in the before times. Are there other diseases that do this or just covid? I was unaware of #glycosylation until now.

#introduction

I have #MECFS #ehlersdanlos #posturalorthostatictachycardiasyndrome #MCAS #immunodeficiency etc..

I spend a lot of time reading research trying to find something to help me be more functional. MCAS was a big cause of pain, but the fatigue portion I haven't made much progress.

Now I'm just trying to not get covid-I don't need new problems. Sadly vaccines don't work on me & reactivated my EBV.

Otherwise I make art, and have kitties, and foster kittens.

First steps here and learning! Time for #introduction part2 with hashtags. I’m a physician-scientist in Helsinki 🇫🇮 (the happiest people on Earth live here!) and topics close to my heart are (not in any order) #thymus #myastheniagravis #aps1 #AIRE #helios #Tfh #tregs #MAITs #RTEs #thymopoiesis #immunodeficiency #immunology #immunophenotyping #flowcytometry #humanimmunology #viruses #viralimmunology #GerminalCenters #SingleCell #Transcriptomics - here to read and learn more about these!

Utility of 3rd vaccine COVID19 dose in immunocompromised children

Humoral and cellular response to the COVID-19 vaccine in immunocompromised children

#COVID19
#vaccine
#children
#immunodeficiency

https://www.nature.com/articles/s41390-022-02374-4

I've continued to mask and avoid situations that are more risky than necessary.
I'm not scared of COVID (I've worked in a pediatric office this whole time) but I respect SARS-CoV2.
I do not think acute infections are the biggest issue. I think #LongCovid #immunodeficiency #cardiovascular #brain and other issues are going to be huge in the coming years.
And the acute infections can become more dangerous again. The public needs to hear the warnings.

https://thetyee.ca/Analysis/2022/11/07/COVID-Reinfections-And-Immunity/

Referenced link: https://medicalxpress.com/news/2022-09-higher-covid-complications-children-immunodeficiency.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2022-09-higher-covid-complications-children-immunodeficiency.html

Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/medical_xpress/status/1570819370166751238#m

RT by @physorg_com: Higher risk of serious COVID-19 complications in #children with #immunodeficiency https://linkinghub.elsevier.com/retrieve/pii/S009167492201185X https://medicalxpress.com/news/2022-09-higher-covid-complications-children-immunodeficiency.html