#MARCH5-dependent #NLRP3 #ubiquitination is required for #mitochondrial NLRP3-NEK7 complex formation and NLRP3 #inflammasome activation
https://www.embopress.org/doi/full/10.15252/embj.2023113481

#immunology @BiomedJ Overview of NOD1 and NOD2 as a mediators of extraintestinal immune responses and review the functions of different members of the #Nodlikereceptor family in orchestrating effector and anamnestic adaptive immune responses in which #inflammasome and non-inflammasome members of this family affect #adaptiveimmunity under various infectious and environmental contexts.
https://www.sciencedirect.com/science/article/pii/S2319417023000744

#Rhinovirus-induced epithelial RIG-I #inflammasome suppresses antiviral #immunity and promotes inflammation in #asthma and #COVID-19 https://www.nature.com/articles/s41467-023-37470-4

'Gefitinib (GF), the tyrosine kinase inhibitor (TKI) targeting epidermal growth factor receptor, initiates lung #inflammation through the NLR family pyrin domain containing 3 (NLRP3) inflammasome. However, the molecular targets and mechanisms underlying the inflammatory action of GF remain unknown. In this study, we identified mitochondrial Src family kinases (mSFKs) as key determinants of GF-induced #NLRP3 #inflammasome activation.'

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200611/238968/The-NLRP3-Inflammasome-Works-as-a-Sensor-for?redirectedFrom=fulltext

How the inflammasome is activated. Almost poetic seeing it in step-wise motion here...

Cryo-EM structures of the active NLRP3 inflammasome disc - https://www.nature.com/articles/s41586-022-05570-8?WT.ec_id=NATURE-20230119&utm_source=nature_etoc&utm_medium=email&utm_campaign=20230119&sap-outbound-id=1540E81EA8A2575BEBC0E3AB32A3412AEAC13A1D

#immunology #cells '#academia #Science #IL1 #inflammasome #infection #cellular #EM

RT @zielinski_cz@twitter.com

Excited about this strong start into 2023 with our new publication in @NatImmunol@twitter.com. #Tcells have membrane holes formed by #GSDME after #inflammasome activation. Read more about this new feature of #Tcells and its role in #inflammation and #hostdefense
https://www.nature.com/articles/s41590-022-01386-w

🐦🔗: https://twitter.com/zielinski_cz/status/1611092450092670988

RT @CancerDoc: #NLRP3 #inflammasome is a double-edged sword in #cancer. NLRP3 activation can be associated with hyper-progression on #PD1 #immunotherapy https://www.science.org/doi/abs/10.1126/scitranslmed.abq7019
#oncology

#NLRP3 #inflammasome is a double-edged sword in #cancer. NLRP3 activation can be associated with hyper-progression on #PD1 #immunotherapy https://www.science.org/doi/abs/10.1126/scitranslmed.abq7019

Congratulations to my friend at the Australian National University Professor Si Ming Man, the recipient of the 2022 Frank Fenner Prize for Life Scientist of the Year at the PM prize in Australia. He has been awarded his prestigious prize for his work on #inflammasome and #bacteria infection. Very well deserved for his groundbreaking work and wonderful recipient. https://www.facebook.com/IndustryGovAu/

Hi Mastodon community, here’s my #introduction I’m a #gastroenterology researcher at #UCL growing #IBD #organoids to investigate #inflammasome regulation and #autophagy

Hi Mastodon community, here’s my #introduction I’m a #gastroenterology researcher at #UCL growing #IBD #organoids to investigate #inflammasome regulation and #autophagy