so, systematically identified conserved, spatially organized anti-tumor immune hubs in solid tumors, associated with #immunotherapy response

many other gene programs still to be explored in anti-tumor hubs
also other hubs such as an #inflammatory hub

now characterizing hubs using MERFISH

next steps to build mouse and organoid models to perturb hubs systematically

2/2

#Vaccinated people have lower levels of #inflammatory markers after #COVID19 infection https://www.news-medical.net/news/20230808/Vaccinated-people-have-lower-levels-of-inflammatory-markers-after-COVID-19-infection.aspx “The study published today in The #Lancet Microbe found among individuals recently infected with #SARSCoV2, those who were fully vaccinated had lower concentrations of almost all #inflammation markers (#cytokines and #chemokines) than those who were #unvaccinated in the short-term and long-term after symptomatic SARS-CoV-2 infection.”

https://arthritistreatment.one/natural-pain-killers/ Natural Pain Killers work better than pharmaceuticals and are safe and effective. Start feeling better without negative side effects. Natural anti inflammatories that help your mind and body feel at their best so you can be and do all you want to do in your life without pain or limitation. #pain #relief #arthritis #inflammatory #health

Severe #COVID19 may lead to long-term innate #immune system changes

> These findings suggest that #SARSCoV2 can cause changes in gene expression that ultimately boost the production of #inflammatory #cytokines and one type of those cytokines perpetuates the process by inducing these changes in stem cells even after the illness is over.

https://www.nih.gov/news-events/news-releases/severe-covid-19-may-lead-long-term-innate-immune-system-changes

Epigenetic memory of #coronavirus infection in innate immune cells and their progenitors

https://www.cell.com/cell/fulltext/S0092-8674(23)00796-1

#Sars2 #covid19

“Initially and during recovery from symptomatic #COVID19, fully #vaccinated participants had lower concentrations of #inflammatory markers than #unvaccinated participants suggesting vaccination is associated with short-term and long-term reduction in #inflammation, which could in part explain the reduced disease severity and #mortality in #vaccinated individuals. https://mstdn.social/@erictopol/110850826870855434

Systemic Medications Linked to an Increased Risk for Skin Malignancy | MDedge Dermatology https://www.mdedge.com/dermatology/article/211646/melanoma/systemic-medications-linked-increased-risk-skin-malignancy.

Useful review “many new drugs that target molecular pathways in #carcinogenesis and the #inflammatory #ImmuneSystem have been developed, resulting in substantial improvements in the treatment of many malignancies and inflammatory conditions. However, an increasingly widespread deployment of these new drugs has revealed an increased tendency for patients to develop #SkinMalignancy”

#Sheriff Recorded Making #Inflammatory Comments Won’t Face Charges
https://www.nytimes.com/2023/06/30/us/oklahoma-sheriff-killing-journalists-lynching.html
#racism #cops #ACAB #police #FTP

Does anyone have any information about #musculoskeletal pain as part of #LongCOVID? Specifically if there are #inflammatory markers that can be tested for in the blood or radiological signs

#Covid

Exquisite control of #LPS-induced #inflammatory signaling: #TDAG51 expressed downstream of Toll-like receptor #TLR stimulation interacts with #FoxO1 and enhances its activity in production of inflammatory mediators
https://www.embopress.org/doi/10.15252/embj.2022111867

#IBD #inflammatory #bowel #disease #awareness

https://arthritistreatment.one/natural-pain-killers/ Natural Pain Killers work better than pharmaceuticals and are safe and effective. Start feeling better without negative side effects. Natural anti inflammatories that help your mind and body feel at their best so you can be and do all you want to do in your life without pain or limitation. #pain #relief #arthritis #inflammatory #health

Proud of the impressive #thesis by the talented Vera Asscher: #Inflammatory #Bowel #Disease; from gut feeling towards evidence-based #medicine

Looking farward to the defence on June 6th 🥳

#geriatrics #MedMastodon #IBD #crohn #colitis

#Glyphosate infiltrates the brain and increases pro-#inflammatory #cytokine TNFα: implications for #neurodegenerative disorders

Published: 28 July 2022

"#Herbicides are #environmental contaminants that have gained much attention due to the potential hazards they pose to human health. Glyphosate, the active ingredient in many commercial herbicides, is the most heavily applied herbicide worldwide. The recent rise in glyphosate application to corn and soy crops correlates positively with increased death rates due to #Alzheimers disease and other #neurodegenerative disorders. Glyphosate has been shown to cross the blood–brain barrier in in vitro models, but has yet to be verified in vivo. Additionally, reports have shown that glyphosate exposure increases pro-inflammatory cytokines in blood plasma, particularly TNFα.

"Collectively, these results show for the first time that glyphosate infiltrates the #brain, elevates both the expression of TNFα and soluble Aβ, and disrupts the transcriptome in a dose-dependent manner, suggesting that exposure to this herbicide may have detrimental outcomes regarding the health of the general population."
#RoundUp #Monsanto #Poison #EPAFail #EPA #Bayer #BigAg

https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-022-02544-5

RT @RastegarS1
We are pleased to share the publication of our collaborative work with @fz_juelich in which we demonstrate #RNA transfer into the #zebrafish embryo and adult using fusogenic #liposomes. Very effective and with low #inflammatory response. https://www.mdpi.com/2241012. @ZebrafishRock

RT @NatureMedicine
Analyses of eight #dietarypatterns revealed that adherence to low insulinemic, low #inflammatory or #diabetes-risk reducing diets was associated with the largest risk reduction of #cardiometabolic diseases and cancer in US men and women. @HarvardChanSPH
https://www.nature.com/articles/s41591-023-02235-5

Most #inflammatory foods, medicines and ingredients you should avoid at all costs #InflammatoryFoods #badmedicine

https://food.news/2023-03-21-top-12-most-inflammatory-foods-medicines-ingredients.html

@rchusid "With COVID-19 added to the mix, Patel now fears a 'perfect storm' of factors will trigger #inflammatory responses in some patients, causing #cancer to arrive years earlier than normal and making it deadlier once it is diagnosed."
#Covid #Covid19 #Inflammation

Most #inflammatory foods, medicines and ingredients you should avoid at all costs

https://food.news/2023-03-21-top-12-most-inflammatory-foods-medicines-ingredients.html

#InflammatoryFoods #badmedicine

Most #inflammatory foods, medicines and ingredients you should avoid at all costs #InflammatoryFoods #badmedicine

https://newstarget.com/2023-03-21-top-12-most-inflammatory-foods-medicines-ingredients.html

Most #inflammatory foods, medicines and ingredients you should avoid at all costs

https://www.naturalnews.com/2023-03-21-top-12-most-inflammatory-foods-medicines-ingredients.html

#InflammatoryFoods #badmedicine