Giuseppe Michieli · @GMIK69
55 followers · 1068 posts · Server mstdn.science
Effect of #ACE #Inhibitor and #ARB Initiation on Organ Support–Free Days in #Patients Hospitalized With #COVID19
A Randomized Clinical Trial - JAMA: https://jamanetwork.com/journals/jama/fullarticle/2803515?guestAccessKey=4694d866-267a-4a5d-9bbb-54479425c945&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=etoc&utm_term=041123
#ace #inhibitor #arb #patients #COVID19
Giuseppe Michieli · @GMIK69
54 followers · 968 posts · Server mstdn.science#Structure-based #design of a #SARS-CoV-2 #Omicron-specific #inhibitor https://www.pnas.org/doi/abs/10.1073/pnas.2300360120?af=R
#structure #design #sars #omicron #inhibitor
Chemistry Research · @organic_chemistry
84 followers · 50 posts · Server mstdn.social
Design of CD73 #inhibitor|s
Introduction of 3' alkynyl moiety led to drastically improved antitumor activity. E. B. Sjogren and colleagues from Calithera Biosciences described the synthesis of these orally available nucleoside analogues in the Journal of Medicinal #Chemistry.
#Research #Science #medchem #chemistry #inhibitor
Chemistry Research · @organic_chemistry
231 followers · 65 posts · Server mstdn.socialDesign of CD73 #inhibitor|s
Introduction of 3' alkynyl moiety led to drastically improved antitumor activity. E. B. Sjogren and colleagues from Calithera Biosciences described the synthesis of these orally available nucleoside analogues in the Journal of Medicinal #Chemistry.
#Research #Science #medchem #chemistry #inhibitor
Marco Radi · @marcoradi
141 followers · 88 posts · Server qoto.org
#CUO246 from #Novartis is a promising DNA #gyrase/#topoisomerase IV dual #inhibitor active against Gram-positive and Gram-negative #bacteria.
https://journals.asm.org/doi/full/10.1128/aac.00921-22
#CUO246 #novartis #bacteria #gyrase #inhibitor