''These results shed light on the mechanisms by which #SARS-CoV-2 evolves to develop #resistance to the current generation of #protease #inhibitors and provide the basis for the design of next-generation #Mpro inhibitors.''
#sars #resistance #protease #inhibitors #mpro
Lindsay Hohsfield will talk about "Using #CSF1R #inhibitors to uncover #myeloid cell trafficking routes into the #CNS"
⏰ September 11th, 2023, 12 pm
📍 @dzne
#csf1r #inhibitors #myeloid #cns
Identification of #SARS-CoV-2 #Mpro #inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2 https://www.nature.com/articles/s41467-023-36729-0
#Efficacy #comparison of #3CLpro #inhibitors #ensitrelvir and #nirmatrelvir against #SARS-CoV-2 in vitro and in vivo https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkad027/7033725?rss=1
#efficacy #comparison #3clpro #inhibitors #ensitrelvir #nirmatrelvir #sars
Bioactive #aurones, #indanones, and other #hemiindigoid #scaffolds: #Medicinal #chemistry and #photopharmacology Perspectives https://dx.doi.org/10.1021/acs.jmedchem.2c01150 #IMBEpapers #inhibition #inhibitors #peptides #proteins #reaction products #selectivity
#aurones #indanones #hemiindigoid #scaffolds #medicinal #chemistry #photopharmacology #imbepapers #inhibition #inhibitors #peptides #proteins #reaction #selectivity
New ‘Parp inhibitors’ could prevent certain tumours appearing | Cancer research | The Guardian #parp #inhibitors #could #prevent #certain #tumours #appearing #cancer #research #guardian #14agosto https://parliamodi.news/article/aHR0cHM6Ly93d3cudGhlZ3VhcmRpYW4uY29tL3NjaWVuY2UvMjAyMi9hdWcvMTQvbmV3LXBhcnAtaW5oaWJpdG9ycy1jb3VsZC1wcmV2ZW50LWNlcnRhaW4tdHVtb3Vycy1hcHBlYXJpbmc=
#14agosto #guardian #research #cancer #appearing #tumours #certain #prevent #could #inhibitors #parp