#IDMastodon #CovidIsNotOver #MaskUp 😷 #GetBoosted @gomez_rial
The chronic pro-inflammatory state was associated with #SarsCoV2 infections in unvaccinated individuals during the 1st wave, due to the action of an uncontrolled #innateimmunity. This phenomenon can be avoided with #covid19vaccination. The immune system after infection is perfectly competent in its functions.

#IDMastodon #Immunology #Innateimmunity & #DNA repair are critical sense-response systems that have evolved to protect cells from external & internal threats: tumors, invading pathogens, toxic agents, physical wounds. Both sys are the focus of intense research & #DrugDiscovery activity to enable more effective therapies for cancer & debilitating #autoimmune & #inflammatorydiseases
https://www.bellbrooklabs.com/wp-content/uploads/2023/08/The-DNA-Damage-Response-and-Innate-Immunity-v08252023.pdf

'In this study, we identified that PRMT3 catalyzes asymmetric arginine dimethylation of RIG-I, MDA5, and cGAS, leading to the inhibition of their activation. As a result, knockdown of Prmt3 in mice can protect mice against both RNA and DNA virus infection.'
#immunology #InnateImmunity

https://www.pnas.org/doi/10.1073/pnas.2214956120

'In this review, we introduce the contribution of numerical changes and functional reprogramming within innate (NK cells, dendritic cells) and adaptive (T cells, B cells) immune cells on the chronic immune dysregulation in the septic murine and human host.'

#immunology #Sepsis #InnateImmunity #inflammation

https://journals.aai.org/jimmunol/article-abstract/211/5/711/265842/The-Calm-after-the-Storm-Implications-of-Sepsis?redirectedFrom=fulltext

@jci_insight Potentially novel transcriptomic evidence that #COVID-19 immune cell responses vary across key patient demographic groups and support inclusion of a diverse patient population in COVID-19 therapeutic trials. Key patient demographics shape #innateimmunity immune topography in noncritical hypoxic #COVID19
https://insight.jci.org/articles/view/166110

'The elucidation of the lipid metabolic pathways that promote innate immune memory contributes to our understanding of trained immunity and may help identify therapeutic tools and targets for the modulation of innate immune responses.'
#immunology #InnateImmunity #Preprint

https://www.biorxiv.org/content/10.1101/2023.08.22.554295v1

#IDMastodon @frontimmunol #Clinicalreviews #Pharmacogenetics & #Pharmacogenomics identified #tumornecrosisfactor as being associated with severe #COVID19
https://www.frontiersin.org/articles/10.3389/fphar.2023.1171404/full
Overview of The clustering in #TNF receptor superfamily signaling in Molecular #innateimmunity
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1225704/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit

The preclinical work on CD47, which binds SIRPα to deliver a 'don't eat me signal', was very compelling. But as a druggable target it's had a bumpy ride in clinical development.

'Pfizer executives were bullish during a second quarter earnings call Thursday that its two CD47 meds would not face the same setbacks seen from rivals Gilead and others. As a result, the New York pharma is staying the course.'
(HT Michael Tomasson)
#Immunology #immunotherapy #InnateImmunity

https://www.fiercebiotech.com/biotech/pfizer-undeterred-cd47-plans-competitors-face-pitfalls

Finally, it’s out! I must say, I am really, really fond of this paper– if you are into #innateimmunity, the #antiviralresponse and #interferon, I think you may enjoy reading it:

https://www.life-science-alliance.org/content/6/10/e202302059

Nothing spectacularly new, but very comprehensive characterization of the #RIGI and #IFN pathway!

"They have investigated the brains of ageing mice, elucidating the source of the cGAS–STING trigger and the particular cells in which this pathway is activated (Fig. 1). Specifically, the authors find that cytosolic DNA derived from perturbed mitochondria activates the pathway in ageing microglia, the main immune cells in the brain — an observation that agrees with earlier findings that cGAS–STING is involved in activating microglia and in neuroinflammation"
#Immunology #Neuroimmunology #NeurodegenerativeDisease #InnateImmunity

https://www.nature.com/articles/d41586-023-02240-1

the great majority of people infected with #SarsCoV2 recovered following asymptomatic infection or having only acute mild to moderate disease, with recovery occurring prior to the onset or peak of #humoralimmunity.The kinetics of infection with recovery in these #COVID19 cases, and that many cases are asymptomatic, underscore a major role for #innateimmunity in early control of #SarsCoV2 infection.

#IDMastodon #Cellimmunity #Immunology @cellpress
Overview #Innateimmunity & #Interferon in #SarsCoV2 infection outcome
Nearly 700 Mil people worldwide have been infected with 🦠 the cause of #COVID19 @WHO 6.8 million people are known to have died from infection. Vaccination clearly protects against #COVID19 severity, wherein humoral immunity is the major biomarker & mediator of disease protection.1 Importantly, prior to vaccination and in nonvaccinated persons today

'Therefore, to understand the influence of Wolbachia on within-host ZIKV evolution, we characterized the genetic diversity of molecularly barcoded ZIKV virus populations replicating in Wolbachia-infected mosquitoes and found that within-host ZIKV evolution was subject to weak purifying selection and, unexpectedly, loose anatomical bottlenecks in the presence and absence of Wolbachia'

#Preprint #Wolbachia #HostPathogen #Virology #InnateImmunity

https://www.biorxiv.org/content/10.1101/2023.06.26.546271v1

'To identify host genes modulating this host-pathogen interaction, we infected 25 Collaborative Cross (CC) mouse strains with methicillin-resistant S. aureus (MRSA USA300) and monitored disease progression for seven days. We identified eight ‘susceptible’ CC strains with high bacterial load, tissue damage, and reduced survival. Among the surviving strains, six with minimal colonization were classified as ‘resistant’, while the remaining six tolerated higher organ colonization (‘tolerant’).'

#Preprint #InnateImmunity #immunology

https://www.biorxiv.org/content/10.1101/2023.07.12.548741v1?med=mas

#IDMastodon #Cellimmunity @cellpress
understanding the #Innateimmunity Roles & the actions of type I & III interferons & they are essential for protection from #SARSCoV2 infection & #COVID19. Each is induced in response to infection & serves to restrict viral replication & spread while directing the polarization & modulation of the adaptive immune response .Contrasting roles of types I & III IFNs in #ViralClearance
https://www.cell.com/immunity/fulltext/S1074-7613(23)00275-3

'Using RNAseq on blood from nine primate species exposed to bacterial lipopolysaccharides, we fit phylogenetic models and discovered hypermetric scaling in innate immune gene responses. We speculate that immune allometries may lead to asymmetrical expectations for virulence of zoonotic pathogens, such that diseases originating in smaller species may cause more severe immunopathology in larger species.'
#InnateImmunity #Inflammation #Sepsis #Immunology #Preprint

https://www.biorxiv.org/content/10.1101/2023.07.11.548565v1

'Overall, our study identifies a previously unrecognized function of STING in negatively regulating anti-fungal immune responses and offers a potential therapeutic strategy for controlling C. albicansinfection.'
#Immunology #InnateImmunity #Fungus

https://www.cell.com/immunity/fulltext/S1074-7613(23)00237-6

'We now provide compelling evidence that in hypoxic conditions, an autocrine IL-24/IL-24-receptor signaling/STAT3 loop is induced, which then sustains the HIF1α-mediated expression of epidermal IL-24. In turn, IL-24 acts in an autocrine and paracrine fashion to coordinate re-epithelialization, re-vascularization, dermal fibroblast proliferation, and collagen deposition to restore the damaged tissue to homeostasis.'
Liu, @mucida, Fuchs et al

#WoundHealing #Immunology #Cytokine #InnateImmunity

https://www.cell.com/cell/fulltext/S0092-8674(23)00328-8

'We demonstrate that while male NK cells display enhanced cellular fitness in mice, they show decreased effector function in mice and humans. These sex biases in NK cell composition and function were not completely due to hormonal differences, because they persisted in gonadectomized mice'

#Immunology #InnateImmunity #NKcels

https://www.nature.com/articles/s41590-023-01463-8

#IDMastodon #ViralImmunology @scisignal understanding how #SarsCoV2 & other coronaviruses use proteases to evade #innateimmunity scientists discuss strides in the study of injury-sensing proteins in #Innateimmune cells
📌 https://www.science.org/doi/10.1126/scisignal.add0082
📌 https://www.science.org/toc/signaling/16/783?utm_campaign=SciSignal&utm_source=Twitter&utm_medium=ownedSocial