RT @RekadZeinab@twitter.com

Question to #celladhesion and #integrin fans, I'm writing my dissertation and I love adding some historical sparks. Shame on me, but I can't seems to find which group did the first ever biochemical characterization of integrin adhesions. (I mean, purification of the complexes)

🐦🔗: https://twitter.com/RekadZeinab/status/1596915315052793856

Question to #celladhesion and #integrin fans, I'm writing my dissertation and I love adding some historical sparks. Shame on me, but I can't seems to find which group did the first ever biochemical characterization of integrin adhesions. (I mean, purification of the complexes)

@soragnilab @MingqingCai @biorxivpreprint the problem with author-selected keywords is they are not helpful unless selected from a controlled vocabulary (e.g. #integrin will not show up in a search for #celladhesion) and then you have to decide/agree on and maintain the taxonomy (which is a nightmare). it's feasible for things like Human Phenotype Ontology, but that's the exception rather than the rule. search normally solves things but here that just means we're back to the original issue

Airway #SmoothMuscleCell #Asthma Inflammation

SMMHC-driven #Integrin α7 transgene in ovalbumin♀️🐭->
⏬Airway leukocyte infiltration
⏬Pulmonary resistance (not compliance)
Re-balanced cytokine/chemokine production

Dr. Mariam Ba lab FASEB Bioadv 2022
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fba.2022-00050

#introduction
Hello, this is Jose M de Pereda and I run a research group at the Center for Cancer Research in #Salamanca (Spain) (#CSIC #USAL).
We study the structural and mechanistic basis of #integrin based #CellAdhesion complexes (mostly #Hemidesmosomes) and of #Rap1 signaling. Knowing in detail how these molecular systems work is essential to understand how they are altered in diseases.
We do multidisciplinary research: #StructuralBiology #Biochemistry, #Biophysics and a bit of #CellBiology

Referenced link: https://phys.org/news/2022-09-chemical-principle-closure-stabilizing-integrin-inhibitors.html
Discuss on https://discu.eu/q/https://phys.org/news/2022-09-chemical-principle-closure-stabilizing-integrin-inhibitors.html

Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/physorg_com/status/1570771314238947328#m

A general chemical principle for creating closure-stabilizing #integrin inhibitors @harvardmed @CellCellPress https://linkinghub.elsevier.com/retrieve/pii/S0092867422009953 https://phys.org/news/2022-09-chemical-principle-closure-stabilizing-integrin-inhibitors.html