RT @WickstromLab
Join us tomorrow, Tue 28th for some exciting science on #integrins and the #extracellularmatrix https://twitter.com/DGZ_info/status/1629921420305113090
#integrins #extracellularmatrix
Tong et al explore the conformational landscape of integrin αIIbβ3 from bent to extended states and the implication for adhesion stability.
"Integrin αIIbβ3 intermediates: From molecular dynamics to adhesion assembly"
https://doi.org/10.1016/j.bpj.2022.12.032
#Integrins #CellAdhesion
Getting more comfortable here and so it’s time for an #introduction ?
I never planned on doing a PhD and certainly not on staying afterwards. But somehow I got hooked on #microscopy and #celladhesion and especially #integrins , more recently also #TGF s. So I stopped my high school teacher career and here I am… And if research also doesn’t work out I might pursue a career in integrin-themed cakes
#introduction #microscopy #celladhesion #integrins #tgf
Biering, S.B., Gomes de Sousa, F.T., Tjang, L.V. et al. #SARS-CoV-2 #Spike triggers barrier dysfunction and #vascular leak via #integrins and #TGF-β signaling. Nat Commun 13, 7630 (2022). https://doi.org/10.1038/s41467-022-34910-5
#sars #spike #vascular #integrins #tgf
@seemasainson @J_Cell_Sci @Dev_journal
#integrins, #transcription factors , #cadhedrins, #phosphoproteomics, #glycomics, #biofilm, #quorum receptors, #idiotype, #immnoglobulin subclass swithcing, #immunogenetics, #cytogenetics, #phylogenetics #metabolmics , #reverse vaccinology, etc.?
#integrins #transcription #cadhedrins #phosphoproteomics #glycomics #biofilm #quorum #idiotype #immnoglobulin #immunogenetics #cytogenetics #phylogenetics #metabolmics #reverse
#introduction:
We are a new cell systems biology team at the #UniversityOfManchester #UoM.
We study #CellAdhesion #networks in health and disease, especially #cancer.
Fascinated by how adhesion proteins help #cells function in so many ways!
#proteomics #integrins #adhesion #cytoskeleton #nucleus #bioinformatics #omics #ExtracellularMatrix #ECM #NetworkBiology #DataViz
#dataviz #networkbiology #ECM #extracellularmatrix #omics #bioinformatics #Nucleus #cytoskeleton #adhesion #integrins #Proteomics #cells #cancer #networks #celladhesion #UoM #UniversityofManchester #introduction
#introductions
I am a Professor in the Dept. of Pharmacological Sciences as well as the Dean for The Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai in New York, USA.
The goal of my research program is to obtain rigorous mechanistic insights into the structure, dynamics, and function of important #membrane #proteins and #drug targets, including #GPCRs, #transporters, #ionchannels, and #integrins.
I am also an editor for #Biophysical Journal
#introductions #membrane #proteins #drug #GPCRs #transporters #IonChannels #integrins #biophysical