Neoadjuvant intratumoral influenza vaccine treatment in patients with proficient mismatch repair colorectal cancer leads to increased tumor infiltration of CD8+ T cells and upregulation of PD-L1: a phase 1/2 clinical trial #oncolytic #immunotherapy #intratumoral #CRC #cancer

https://jitc.bmj.com/content/11/5/e006774

Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial #cancer #brain #viraltherapy #intratumoral

"Oncolytic viruses are capable of reconditioning the tumor microenvironment toward a ‘hot’ phenotype, providing rationale for combinatorial therapy with checkpoint inhibitors"

https://www.nature.com/articles/s41591-023-02347-y