A new paper from @wu_xuebing 's lab just published @Nature
"Noncoding translation mitigation"

nature.com/articles/s41586-023

Here are my thoughts:
It is a very interesting paper, and important to anyone working on , particularly from , but not only.
In brief, they screened short sequences originating from or from non coding regions ( ) (and CDS as control) which they fused to GFP at the C-term and looked at GFP expression level.
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#mRNA #intron #utr #lncRNA #ncrnas #translation

Last updated 2 years ago

Keith Bradnam πŸ“ˆ · @kbradnam
275 followers · 129 posts · Server hachyderm.io

I stopped being a research scientist over six years ago but I still receive Google Scholar alerts when my publications are cited.

This week a new paper about length prominently cited some work I led on. This is the new paper:

β€˜The position of the longest intron is related to biological functions in some human genes’

ncbi.nlm.nih.gov/pmc/articles/

#intron

Last updated 2 years ago

Jill Townley · @citsci
24 followers · 7 posts · Server genomic.social

Have any antisense oligonucleotide experts made it onto mastodon?

I'm trying to find evidence on how much of a role secondary structure remediation plays in splice-switching ASO design. A presentation by an ASO researcher from a biotech stated that the recognizes intron , particularly the intron 5' structure, but haven't found published evidence or hypothesis.

-mRNA

#aso #intron #spliceosome #secstruct #pre #splicing

Last updated 2 years ago

Steve Baker · @Bakersm11
0 followers · 101 posts · Server theblower.au

#intron

Last updated 2 years ago