Synthesis of highly complex terpenoids reported by Shuanhu Gao and co-workers from the East China Normal #University (#Shanghai #China). Cephinoid P and other related terpenoids were accessible by Nicholas/Hosomi-Sakurai cascade reaction and Pauson-Khand reaction. Published in #JACS

#chemistry #TotalSynthesis

https://pubs.acs.org/doi/10.1021/jacs.3c05455

The beauty of spirocyclic compounds: Total synthesis of illisimonin A by Markus Kalesse and co-workers from the University Hannover published recently in #JACS

Nazarov/ene cyclization lead to key intermediate for the #synthesis of this terpenoid.

#totalsynthesis #chemistry #science #research

https://pubs.acs.org/doi/10.1021/jacs.3c01262

Stephadiamine is a popular synthetic challenge which resulted in many total syntheses before. Now, Jieping Zhu (EPFL, Lausanne) and co-workers were able to report in #JACS a new route to the #alkaloid with a hasubanan core structure featuring a diastereoselective intramolecular dipolar cycloaddition.

https://doi.org/10.1021/jacs.3c00884

#chemistry #totalsynthesis

#Science #Research #Nanomaterials #Semiconductors #ColloidalChemistry #UniRostock #SwanseaResearch #JACS
Together with the group of Zhongwu Wang (Cornell), we published a new paper in JACS on the nucleation and growth of nanocrystal superlattices
https://pubs.acs.org/doi/10.1021/jacs.2c11120

Latest #paper from the group, in #JACS! Chamoni and co-workers demonstrate #polymer materials that undergo "fueled" transient changes in mechanical properties on treatment with carbodiimides, enabling cool applications like temporary adhesion and rewriteable film patterning.

Part of our long collaboration with @konkol, with materials characterization help from the Sparks group, both at #MiamiUniversity

https://pubs.acs.org/doi/10.1021/jacs.3c00668

#chemistry @chemistry

"Z-Trisubstituted α,β-Unsaturated Esters and Acid Fluorides through Stereocontrolled Catalytic Cross-Metathesis" published in #JACS by Hoveyda and co-workers (Boston College, #USA).
#chemistry #orgchem @chemistry
https://pubs.acs.org/doi/10.1021/jacs.2c13245

Nowadays, a lot of total #synthesis projects include terpenes with a C-H functionalization strategy.

In contrast, Alois Fürstner and co-workers (MPG Mülheim) recently presented their synthesis of prorocentin, a complex #polyketide, in #JACS featuring up-to-date transformations and beautifully designed synthetic routes. I added this synthesis now to my collection, have a look 👇

https://www.organicchemistry.eu/books/total-syntheses-of-natural-products/page/first-total-synthesis-and-structural-revision-of-prorocentin-a-furstner-2023

#chemistry @chemistry

Synthesis of prorocentin by Alois Fürstner and co-workers from MPI Mülheim a.d. Ruhr @maxplanckgesellschaft published in #JACS is a showcase of why total synthesis is still needed: Determination of the absolute configuration and structural revision was only possible after extensive synthetic efforts.

https://pubs.acs.org/doi/10.1021/jacs.2c12529

#chemistry #totalsynthesis @chemistry

Can you get cyclopropanes from 1,2-diketones. You can! Chun-Xiang Zhou and co-workers from the Xiamen University (#China) demonstrated this in the journal #JACS. A salen-type #catalyst with Mo as the active metal centre mediates this reductive reaction.

A truly powerful method with the potential of follow-up work for a more general substrate scope.

https://pubs.acs.org/doi/10.1021/jacs.2c12225

#chemistry #orgchem #synthesis @chemistry

You can play many chemical games with #perovskites. Removing inversion symmetry is one where the rules are still being written #JACS #Chemiverse #Chemistry https://pubs.acs.org/doi/abs/10.1021/jacs.2c12034

@davidschnettler and the Hollfelder-team have used #DirectedEvolution to breed new phosphotriesterases that could be useful for bioremediation or treatment of organophosphate intoxication. Active #enzyme variants were retrieved from large libraries packaged in tiny droplets on a #microfluidics platform.

Now in #jacs
https://pubs.acs.org/doi/full/10.1021/jacs.2c10673

Total synthesis of Alterbrassicene C:

John L Wood (Baylor University, #US) et al reported the first total synthesis of the terpenoid in #JACS (10.1021/jacs.2c12275). I feautered this #synthesis because I like these kinds of oxa-Michael cascade reactions. Since many terpenoid syntheses these days often involve CH activation strategies, it's refreshing to see other approaches in action.

Read more: https://www.organicchemistry.eu/books/total-syntheses-of-natural-products/page/total-synthesis-of-alterbrassicicene-c-j-l-wood-2022

@chemistry #chemistry #totalsynthesis #terpene

Total synthesis of (−)-GA18 Methyl Ester reported by Mingji Dai from Emory University (Atlanta, #US ) published recently in #JACS featuring a skeletal rearrangement

https://pubs.acs.org/doi/10.1021/jacs.2c12470

#chemistry #totalsynthesis #organicchemistry @chemistry

Check out our recent work in #jacs about the CVD and micrometric patterning of Cu-BHT nanometric films.
https://pubs.acs.org/doi/10.1021/jacs.2c09007

Wednesday morning read #chemistry #jacs

Wednesday morning read #chemistry #jacs

Almost two years in the making this is really cool #chemistry published in #JACS #ChemiVerse @chemistry @compchem
https://pubs.acs.org/doi/10.1021/jacs.2c09637

I had some time to highlight the total synthesis of salimbromide from H. Lu (Westlake University, China) published two months ago in #JACS . Main selling point is the extrem short synthetic route (only 8 steps), half of the steps used before.

#chemistry #totalsynthesis @chemistry

https://www.organicchemistry.eu/books/total-syntheses-of-natural-products/page/total-synthesis-of-salimabromide-hai-hua-lu-2022

Interesting #Monday read: Total synthesis of Luminamicin by Tomoyasu Hirose and Toshiaki Sunazuka and co workers (Kitasato University, Tokyo) published in #JACS

Extremly challenging synthetic route, in the end using common intermediate from degredation route and synthesis route to finish the natural product.

#chemistry #totalsynthesis @chemistry

https://pubs.acs.org/doi/10.1021/jacs.2c10856

📰 Nickel catalyzed coupling of acyl chlorides and aldehydes for the enantioselective synthesis of α hydroxy ketones.

Liang-An Chen (#Nanjing Normal University) and colleagues described the formation of acyl nickel which can react with in situ generated α-oxy bromides. Published in #JACS

https://pubs.acs.org/doi/10.1021/jacs.2c10072

@chemistry #chemistry #organicchemistry