Felicity Sterling, Kevin Vaughan and colleagues identify StARD9 as a novel lysosomal kinesin required for LE/L tubulation. Depletion of StARD9 induces accumulation of cholesterol, a signature of Niemann–Pick type C (NPC) disease.
https://journals.biologists.com/jcs/article/136/5/jcs260662/292582/StARD9-is-a-novel-lysosomal-kinesin-required-for

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Find out more about the research in our ‘First person’ interview with Felicity Sterling:
https://journals.biologists.com/jcs/article/136/5/jcs261051/292580/First-person-Felicity-Sterling

#cellbiology

Endosome sorting sorted!
In their Review, Vaishnavi Ananthanarayanan and Greg Redpath discuss recent studies on the regulation of endosomal vesicle positioning and transport by motors and adaptors.

https://journals.biologists.com/jcs/article/136/5/jcs260749/292583/Endosomal-sorting-sorted-motors-adaptors-and

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Reto Gassmann reviews the current knowledge of dynein function and regulation at the kinetochore and highlights parallels in regulation of dynein at other subcellular locations.

https://journals.biologists.com/jcs/article/136/5/jcs220269/291809/Dynein-at-the-kinetochore

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#cellbiology #molecularmotors

Kyoko Chiba, Shinsuke Niwa and colleagues review the role and regulation of KIF1A in axonal transport, discussing how studying disease-associated mutations of KIF1A has revealed new insights into the function and regulation of the motor.

https://journals.biologists.com/jcs/article/136/5/jcs260742/286709/Insight-into-the-regulation-of-axonal-transport

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#cellbiology #molecularmotors

In our #JCSCellBiologyofMotors Special Issue, our ‘Cell Scientists to watch’ interview is with Jordan Beach and Patrick Oakes. Check out the interview to find out more about their career paths, where they see the mechanobiology field heading and advice for new PIs.

https://journals.biologists.com/jcs/article/136/5/jcs260939/288520/Cell-scientists-to-watch-Jordan-Beach-and-Patrick

When asked about the advantages of running a joint lab, Jordan’s response was:
“More people, more fun, better science. I think that's what it really comes down to.”

#cellbiology #molecularmotors

Melissa Quintanilla, John Hammer and Jordan Beach share the wonders of non-muscle myosin 2 in their ‘Cell Science at a Glance’ article and poster.

https://journals.biologists.com/jcs/article/136/5/jcs260890/297120/Non-muscle-myosin-2-at-a-glance

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#cellbiology #molecularmotors

In their #OpenAccess Review, Marlieke Jongsma, Nina Bakker & Jacques Neefjes describe the endosomal dance, and its coordination by molecular motors, which transports lipids, proteins and nutrients in the cell.

https://journals.biologists.com/jcs/article/136/5/jcs259689/282885/Choreographing-the-motor-driven-endosomal-dance

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#cellbiology #cellbio

Go with the flow – bulk transport by molecular motors

Wen Lu and Vladimir Gelfand discuss the roles of molecular motors in cytoplasmic streaming.

https://journals.biologists.com/jcs/article/136/5/jcs260300/277621/Go-with-the-flow-bulk-transport-by-molecular

#JCSCellBiologyofMotors #cellbiology #molecularmotors

Alf Månsson reflects on the possibilities and challenges in using actin and myosin in nanobiotechnological applications, such as biosensing and parallel computation.
https://journals.biologists.com/jcs/article/136/5/jcs261025/292584/The-potential-of-myosin-and-actin-in
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In their Review, Kristen Verhey and Ryoma Ohi discuss how kinesin motors alter the microtubule lattice as they move and what the downstream allosteric interactions mean for intracellular transport and the microtubule dynamics.
https://journals.biologists.com/jcs/article/136/5/jcs260735/293511/Causes-costs-and-consequences-of-kinesin-motors

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Our cover image for #JCSCellBiologyofMotors depicts the association of mature vaccinia virions expressing a fluorescent core protein (cyan) with microtubules (orange) in vitro. See the full Research Article from Xu et al.: https://journals.biologists.com/jcs/article/136/5/jcs260175/276937/Kinesin-1-transports-morphologically-distinct

Other highlights include:
- Interview with Jordan Beach & Patrick Oakes
- Motors in nanobiotech
- Motors in artificial systems
- Non-muscle myosin 2 poster
- Reviews on kinesins, endosomal sorting, dynein, plus axonal, endosomal & bulk transport

Our Special Issue: Cell Biology of Motors, guest edited by @AnneStraube @Warwick_CMCB, is now complete!

Check out the full Table of contents and Anne’s Editorial here:
https://journals.biologists.com/jcs/issue/136/5
https://journals.biologists.com/jcs/article/136/5/jcs261056/297105/The-cell-biology-of-motors
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You can find out more about Anne's research career in her interview in our ‘Cell Scientists to Watch’ series.

https://journals.biologists.com/jcs/article/136/5/jcs260852/286218/Interview-with-the-Guest-Editor-Anne-Straube