Sophie Dumont at UCSF
http://www.dumontlab.ucsf.edu/

#Chromosome size alters #kinetochore attachment stability and alignment order in mammalian #mitosis

Lab interested in #SelfOrganization and emergent mechanics across scales.... "biological structures build themselves" using only local cues they get global information. mitotic spindle a great example

kinetochores attach, sense tension, can make mistakes which are corrected. how does this work when chromosomes vary in size?

#CSSingleCells23

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Pulling its weight: Team identifies #protein key to #chromosome movement during cell division.

#mitosis #anaphase #CENP_C #kinetochore

https://phys.org/news/2023-06-weight-team-protein-key-chromosome.html

Why is a short loop in the extended #Ndc80 #kinetochore complex essential for #mitosis?
In vitro studies by Soumitra Polley @andreamusacchio @microtubule_guy @pim et al reveal its contribution to end-on #microtubule attachment via homotypic interactions between adjacent Ndc80 molecules
https://www.embopress.org/doi/10.15252/embj.2022112504

New insights into #centromere structure.

#CENP_A #interphase #kinetochore

https://phys.org/news/2023-02-insights-centromere.html

How do #yeast adapt to #chromatinization with human #histones and subsequent #aneuploidy?

Jeff Boeke, @maxhaase et al from NYU Langone find #ploidy stabilization by DASH/Dam1 complex mutants that weaken #kinetochore-#microtubule attachment strength

https://www.embopress.org/doi/10.15252/embj.2022112600

RT @SmartBiology3D@twitter.com

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