#Aneuploidies are an ancestral feature of #trypanosomatids, and an ancient chromosome #duplication is maintained in extant species

João Luís Reis-Cunha et al
bioRxiv 2023.06.26.546280; doi: https://doi.org/10.1101/2023.06.26.546280

#leishmania #genome #genomics #aneuploidy

"Here, we tested the ability of the #leishmania major sphingolipids inositol phosphorylceramide (IPC), and ceramide to shelter ergosterol by preventing binding and cytotoxicity of the sterol-specific toxins streptolysin O and perfringolysin O using flow cytometry. In contrast to mammalian systems, Leishmania sphingolipids did not preclude toxin binding to sterols in the membrane. However, IPC interfered with cytotoxicity."

#Preprint

https://www.biorxiv.org/content/10.1101/2022.06.15.496300v3#review

New personal view article in The Lancet Infectious Diseases> Hidden sources of bias in diagnostic studies: the example of visceral #leishmaniasis in east Africa https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00643-0/fulltext#.Y3Sfl_o0UTk.twitter #Leishmania

Referenced link: https://phys.org/news/2022-08-pathogenic-leishmania-parasite-evolution-cell.html
Discuss on https://discu.eu/q/https://phys.org/news/2022-08-pathogenic-leishmania-parasite-evolution-cell.html

Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/physorg_com/status/1562104913789947904#m

New study on pathogenic #Leishmania parasite sheds light on evolution of cell's force-producing machinery @helsinkiuni @NatureComms https://www.nature.com/articles/s41467-022-31068-y https://phys.org/news/2022-08-pathogenic-leishmania-parasite-evolution-cell.html