can build networks that are impressively cell type-specific

using to predict responses to environmental influences, in macrophages
see Fig 1B of the recent paper:
https://www.embopress.org/cms/asset/7c1cf42a-6d58-42b5-9f5d-18a4430cca2c/msb202311627-fig-0001-m.jpg
(caption here: https://www.embopress.org/doi/full/10.15252/msb.202311627#)

now turning to #BoneMarrow #StemCells and #leukemia, specifically #AML

2/2

PhD in Chromatin Biology

University College Dublin

#PhD position available at University College Dublin to work on the mechanisms of #enhancer dysregulation in acute myeloid #leukemia.

See the full job description on jobRxiv: https://jobrxiv.org/job/university-college-dublin-27778-phd-in-chromatin-biology/?feed_id=51768

#ScienceJobs #hiring #research #chromatin #transcription #enhancers #cance...
https://jobrxiv.org/job/university-college-dublin-27778-phd-in-chromatin-biology/?feed_id=51768

Sigh. Not this year. Moving to Boston for three months to take care of my sister after her stem cell transplant.

#oshkosh
#eaa
#leukemia
#leukemiasucks bb

"#Gypsy" is a song by British-American #rock band #FleetwoodMac. The song was written by #StevieNicks around 1979; the earliest demo recordings were made in early 1980 with #TomMoncrieff for possible inclusion on her debut solo album #BellaDonna. However, when Nicks' close friend Robin Anderson died of #leukemia, the song took on a new significance and Nicks held it over for Fleetwood Mac. "Gypsy" was the second single release.
https://youtu.be/RqjXn2NflqU

New #PLOSBiology study reveals the crucial role of splicing in TAL1 isoform regulation and its impact on hematopoiesis. These findings highlight the potential of targeting splicing to combat cancer. #CancerResearch #leukemia
https://plos.io/3CTaslQ

When A Brave Bear Fights Cancer:A Get Well Soon Gift, by Carola Schmidt. Teddy bear Scottie is shocked to learn he has #leukemia. With help from friends, Nurse Bree and Dr Caddy he bravely fights on.
#picturebooks #bookstodon #cancer

An off-the-shelf CART story at NEJM.

"And at the same time, we’re now tackling a different type of leukemia, T-cell leukemia. So in combination, three editing steps to remove molecules on the surface of T cells to allow them to be used off the shelf and to be able to have those cells ready, premanufactured and frozen, and to be able to give them in a timed way to patients who otherwise would not have treatment options."

#immunotherapy #Immunology #Hematology #Leukemia

https://www.nejm.org/doi/full/10.1056/NEJMp2303851?query=featured_home

💪💪 'Terrific Progress': Adding #Blinatumomab for #Infant #Leukemia

📌 The immunotherapy blinatumomab improves short-term outcomes when added to standard chemotherapy for infants with KMT2A-rearranged acute lymphoblastic leukemia (ALL)

📌 "These outcome data are very promising, given the poor survival and lack of improvements in outcomes among infants with KMT2A-rearranged ALL in recent decades,"

https://www.nejm.org/doi/full/10.1056/NEJMoa2214171

https://www.medscape.com/viewarticle/991614?src=rss&icd=login_success_email_match_norm#vp_1

#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer

#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer

#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer

Join us Thurs, May 4, at noon CT/1 pm ET as Dr. Sarah K. Tasian of Children’s Hospital of #Philadelphia presents “Emerging Therapies for Pediatric Leukemia.” Tasian will review the biology of childhood B-acute lymphoblastic #leukemia and discuss emerging precision medicine therapies and #immunotherapeutic approaches for specific leukemia subtypes. Register. https://bit.ly/SOCC23-MAS #SOCC23 #AcuteLymphoblasticLeukemia #PrecisionMedicine #Immunotherapy

Vandaag exclusief nieuws in de Volkskrant van mijn hand:

Nederlands onderzoek betekent doorbraak in behandeling baby’s met leukemie
https://www.volkskrant.nl/a-b31512cd

#leukemie #ALL #baby #kika #kanker #kinderkanker #nejm #science #leukemia

Referenced link: https://medicalxpress.com/news/2023-04-clinical-trial-immunotherapy-strongly-prognosis.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-04-clinical-trial-immunotherapy-strongly-prognosis.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1651330315300765696#m

RT by @physorg_com: Clinical trial: Immunotherapy strongly improves prognosis of #babies with #leukemia @nejm https://medicalxpress.com/news/2023-04-clinical-trial-immunotherapy-strongly-prognosis.html

'Our data indicate that E2a suppresses leukemogenesis by promoting T cell development and enforcing inter-thymocyte competition, a mechanism that is emerging as a safeguard against thymocyte transformation.'
#Preprint #Immunology #Leukemia

https://www.biorxiv.org/content/10.1101/2023.04.23.537993v1?med=mas

Senior Research Technologist @CanerSaygin

The Senior Research Technologist will work on research projects involving both in vitro and in vivo investigations in leukemia.

https://jobrxiv.org/job/university-of-chicago-27778-senior-research-technologist/?feed_id=43506

#ScienceJobs #job #leukemia #leusm #genomics #transg...
https://jobrxiv.org/job/university-of-chicago-27778-senior-research-technologist/?feed_id=43506

#OnThisDay Birth Anniversary of George H. Hitchings (1905). He received 1988 Nobel Prize in Physiology or Medicine for his work on #Chemotherapy and development of the two first successful chemotherapy drugs for the treatment of children with #Leukemia.

Today is International Day For #Monuments and Sites.

https://knowledgezone.co.in/news

RT @Mom_von_PauL
Bitte lasst euch registrieren wenn ihr könnt 🙏🏻

#blutkrebs #cancer #leukemia #leukämie #fuckcancer #lebenretten #dkms #childhoodcancer https://twitter.com/DKMS_de/status/1639293507889254402

I got an email today that I have been in the Be the Match registry, which helps find bone marrow donors for folks with life-threatening blood cancers like leukemia and lymphoma, for 11 years.

If you're interested in becoming a potential donor, you should sign up today!

https://bethematch.org/

#BeTheMatch #cancer #lymphoma #leukemia

https://www.optimistdaily.com/2023/03/revumenib-the-breakthrough-pill-curing-leukemia-in-a-third-of-patients/?utm_source=rss&utm_medium=rss&utm_campaign=revumenib-the-breakthrough-pill-curing-leukemia-in-a-third-of-patients #leukemia #GoodNews