“Structural insights into the mechanism of the human SGLT2-MAP17 glucose transporter”

More structures of the #LeuT fold #transporter SGLT2 in multiple conformations. Some interesting results with the driving ion sodium

https://www.biorxiv.org/content/10.1101/2023.01.23.524988v1

"Cyclic di-AMP traps proton-coupled K+ transporters of the KUP 1 family in an inward-occluded conformation"

Another structure of the #LeuT-fold potassium #transporter KimA shows how it is inhibited by cyclic di-AMP binding. #StructBio #CryoEM

https://www.biorxiv.org/content/10.1101/2023.01.09.523207v1

“Structural and functional properties of a plant NRAMP related aluminum transporter”

Another #transporter structure with the #LeuT fold, this one transports metal ions like aluminum. Amazing how 45-50kDa membrane protein cryo structures are now routine…

https://www.biorxiv.org/content/10.1101/2022.12.21.521437v1