A nice new #paper where I have played a small part. An extremely surprising finding where mutants in the 5S #ribosomal #RNA #transcription factor #GTF3A causes enhanced #susceptibility to #HSV #virus #infection, leading to #encephalitis. A #pseudogene #transcribed is a #ligand activating #RIG-I.
https://pubmed.ncbi.nlm.nih.gov/36399538/
#fediscience #immunology #science #PID #genetics #signaling #herpes #health
#health #herpes #signaling #genetics #pid #science #immunology #Fediscience #rig #ligand #transcribed #pseudogene #encephalitis #infection #virus #hsv #susceptibility #gtf3a #transcription #rna #ribosomal #paper
Just joined and testing this new platform, time for an #introduction!
We are a #biochemistry and #structuralbiology laboratory based in #Pavia, #Italy.
#wemakeproteins and are fascinated by the #extracellular space: we study how #collagen contributes to the assembly of the #ECM and we perform #drugdiscovery studies on #enzymes of collagen #biosynthesis, plus we investigate various #ligand - #receptor #interactions leading to #signaling in humans and in insects.
Always open to #collaboration.
Check our website and help us grow: http://fornerislab.unipv.it/armenise_lab/
#biochemistry #Pavia #italy #collaboration #introduction #structuralbiology #wemakeproteins #extracellular #collagen #ecm #drugdiscovery #enzymes #biosynthesis #ligand #receptor #interactions #signaling
Nice paper from the Schapira lab identifying potential #ligand binding pockets for future #PROTAC development.
https://www.sciencedirect.com/science/article/pii/S2001037022005049#b0040
I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup
#hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #ChemicalBiology #biochem #cellbiology #biotech #biopharma #ligase #Ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup