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The EMBO Journal · @embojournal
451 followers · 200 posts · Server sciencemastodon.com
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Extensive multivalent interactions between intrinsically disordered regions in the /#BARD1 and substrates facilitate recruitment and contribute to histone H2A and
Sam Witus, Rachel Klevit, Weixing Zhao et al
embopress.org/doi/10.15252/emb

#brca1 #e3 #ligase #nucleosome #chromatin #ubiquitylation #DNARepair

Last updated 1 year ago
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The EMBO Journal · @embojournal
441 followers · 172 posts · Server sciencemastodon.com
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What controls basal, -independent ?

E3 screen by Sylvie Urbé, Michael Clague and coworkers identifies and as negative regulators of mitophagy receptors and via transcriptional and direct post-translational mechanisms, respectively

embopress.org/doi/10.15252/emb

#parkin #mitophagy #Ubiquitin #ligase #vhl #fbxl4 #nix #bnip3

Last updated 2 years ago
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CellBioNews · @cellbionews
49 followers · 1109 posts · Server scientificnetwork.de

#RNA #repair #ligase #c12orf29 #crispr #chemoproteomic

Last updated 2 years ago
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The EMBO Journal · @embojournal
411 followers · 102 posts · Server sciencemastodon.com
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EMBO Journal Issue 4/23:
- Commentary on needs in research
- recognition in orphan complex subunits by CLR4-DCAF12 E3
- topography of receptors
- roles and regulation in
- interplay with severing

Cover by Satarupa Bhaduri, Analine Aguayo, Sonya Neal et al
embopress.org/toc/14602075/202

#creativity #degron #Ubiquitin #ligase #plasmamembrane #IgM #Bcell #yap #tumorigenesis #brassinosteroid #katanin #microtubule

Last updated 2 years ago
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The EMBO Journal · @embojournal
411 followers · 98 posts · Server sciencemastodon.com
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Viral mimicry of a adaptor: shows how rodent E27/M27 hijacks host cell -RING E3s to degrade and suppress signaling
embopress.org/doi/10.15252/emb

#dcaf #Ubiquitin #ligase #cryoem #cytomegalovirus #cmv #crl4 #cullin #stat2 #Antiviral #interferon

Last updated 2 years ago
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The EMBO Journal · @embojournal
406 followers · 89 posts · Server sciencemastodon.com
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- represses of T-helper 2-specific negative regulators during :
Brd4 interacts with repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators and E3 during lineage-specific differentiation of cells from mouse primary naïve CD4+ T cells
embopress.org/doi/10.15252/emb

#brd4 #prc2 #transcription #Tcell #differentiation #polycomb #foxp3 #ubiqutin #ligase #fbxw7 #th2

Last updated 2 years ago
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The EMBO Journal · @embojournal
403 followers · 85 posts · Server sciencemastodon.com
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Protein complex assembly in action:
structures by Nico Thomä at FMI and colleagues show how - E3 engages a C-terminal di-Glu in CCT5 recognizable only when this subunit is not incorporated into the /#CCT complex
embopress.org/doi/10.15252/emb

#qualitycontrol #cryoem #crl4 #dcaf12 #Ubiquitin #ligase #degron #tric #chaperone

Last updated 2 years ago
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The EMBO Journal · @embojournal
364 followers · 57 posts · Server sciencemastodon.com
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Unusual interplay in :
Bin Zhao, Xin-Hua Feng and colleagues Zhejiang University show that blocks /#TAZ recognition and degradation via - independent of its own E3 activity
embopress.org/doi/10.15252/emb

#Ubiquitin #ligase #hippo #signaling #herc3 #yap #scf #betatrcp

Last updated 2 years ago
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Scientific European · @ScientificEuropean
243 followers · 284 posts · Server toot.community

Discovery of a novel human that functions as first report of such in higher | RNA ligases play an important role in , thereby maintaining RNA integrity. Any malfunction in RNA repair in humans seems to be associated with like and Discovery of a novel human protein (C12orf29 on chromosome 12) as an RNA ligase....

scientificeuropean.co.uk/news-

#protein #RNA #ligase #eukaryotes #rnarepair #diseases #neurodegeneration #cancer

Last updated 2 years ago
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Katherine Reiter · @kreiter
86 followers · 4 posts · Server mstdn.science

#introduction #broadinstitute #Cambridge #Ubiquitin #ligase #structuralbiology #mechanisms #Science #biotech #DrugDiscovery #ChemicalBiology #TPD #targetedproteindegradation #biophysics #biochemistry #HDX #NMR #SAXS #cryoem

Last updated 2 years ago
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CRAIG M CREWS · @crews
350 followers · 142 posts · Server mstdn.science

#hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #ChemicalBiology #biochem #cellbiology #biotech #biopharma #ligase #Ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup

Last updated 2 years ago
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