Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565
#brca1 #e3 #ligase #nucleosome #chromatin #ubiquitylation #DNARepair
What controls basal, #Parkin-independent #mitophagy?
E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively
#parkin #mitophagy #Ubiquitin #ligase #vhl #fbxl4 #nix #bnip3
Hidden #RNA #repair mechanism discovered in humans.
#ligase #C12orf29 #CRISPR #chemoproteomic
https://phys.org/news/2023-04-hidden-rna-mechanism-humans.html
#RNA #repair #ligase #c12orf29 #crispr #chemoproteomic
EMBO Journal Issue 4/23:
- Commentary on #creativity needs in research
- #Degron recognition in orphan complex subunits by CLR4-DCAF12 E3 #ubiquitin #ligase
- #Plasmamembrane topography of #IgM #Bcell receptors
- #YAP roles and regulation in #tumorigenesis
- #Brassinosteroid interplay with #katanin #microtubule severing
Cover by Satarupa Bhaduri, Analine Aguayo, Sonya Neal et al
https://www.embopress.org/toc/14602075/2023/42/4
#creativity #degron #Ubiquitin #ligase #plasmamembrane #IgM #Bcell #yap #tumorigenesis #brassinosteroid #katanin #microtubule
Viral mimicry of a #DCAF #ubiquitin #ligase adaptor: #CryoEM shows how rodent #cytomegalovirus #CMV E27/M27 hijacks host cell #CRL4 #cullin-RING E3s to degrade #STAT2 and suppress #antiviral #interferon signaling
https://www.embopress.org/doi/10.15252/embj.2022112351
#dcaf #Ubiquitin #ligase #cryoem #cytomegalovirus #cmv #crl4 #cullin #stat2 #Antiviral #interferon
#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473
#brd4 #prc2 #transcription #Tcell #differentiation #polycomb #foxp3 #ubiqutin #ligase #fbxw7 #th2
Protein complex assembly #qualitycontrol in action:
#cryoEM structures by Nico Thomä at FMI and colleagues show how #CRL4-#DCAF12 #ubiquitin E3 #ligase engages a C-terminal di-Glu #degron in CCT5 recognizable only when this subunit is not incorporated into the #TRiC/#CCT #chaperone complex
https://www.embopress.org/doi/10.15252/embj.2022112253
#qualitycontrol #cryoem #crl4 #dcaf12 #Ubiquitin #ligase #degron #tric #chaperone
Unusual #ubiquitin #ligase interplay in #Hippo #signaling:
Bin Zhao, Xin-Hua Feng and colleagues Zhejiang University show that #HERC3 blocks #YAP/#TAZ recognition and degradation via #SCF-#betaTrCP independent of its own E3 activity
https://www.embopress.org/doi/10.15252/embj.2022111549
#Ubiquitin #ligase #hippo #signaling #herc3 #yap #scf #betatrcp
Discovery of a novel human #protein that functions as #RNA #ligase first report of such #protein in higher #eukaryotes | RNA ligases play an important role in #RNArepair, thereby maintaining RNA integrity. Any malfunction in RNA repair in humans seems to be associated with #diseases like #neurodegeneration and #cancer Discovery of a novel human protein (C12orf29 on chromosome 12) as an RNA ligase....
#protein #RNA #ligase #eukaryotes #rnarepair #diseases #neurodegeneration #cancer
#introduction I am a research scientist at the #BroadInstitute in #Cambridge with an interest in #Ubiquitin #ligase #structuralbiology and #mechanisms. Here for the #science toots about #biotech #DrugDiscovery #ChemicalBiology #TPD #targetedproteindegradation #biophysics #biochemistry #HDX #NMR #SAXS #CryoEM
#introduction #broadinstitute #Cambridge #Ubiquitin #ligase #structuralbiology #mechanisms #Science #biotech #DrugDiscovery #ChemicalBiology #TPD #targetedproteindegradation #biophysics #biochemistry #HDX #NMR #SAXS #cryoem
I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup
#hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #ChemicalBiology #biochem #cellbiology #biotech #biopharma #ligase #Ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup