Are there functions specific to #CUL4A and #CUL4B-based #ubiquitin E3 #ligases?
Matthias Peter Lab, Anna Stier et al find a CUL4B-specific N-terminal extension undergoing heavy #mitotic #phosphorylation, and promoting recruitment of a specific set of #DCAF substrate receptors involved in #cytoskeleton regulation
#cul4a #cul4b #Ubiquitin #ligases #mitotic #phosphorylation #dcaf #cytoskeleton
Featured in issue 23 of our anniversary year:
How delayed folding aids #protein secretion
Plant and mammalian #ubiquitin E3 #ligases against #bacterial #infection
#CryoEM glimpses at membrane pore formation and #ion transporters
#Autophagosomes in need of balanced #phospholipid composition
#Hypoxia promotes #osteogenesis by facilitating #mitochondria to
#nucleus communication
Cover by by Subhash Mehto, Kautilya Kumar Jena, Santosh Chauhan et al
https://www.embopress.org/toc/14602075/2022/41/23
#protein #Ubiquitin #ligases #bacterial #infection #cryoem #ion #autophagosomes #phospholipid #Hypoxia #osteogenesis #mitochondria #nucleus