Linezolid probably a bit safer than we think & probably can give >4 weeks with close observation.

Great drug, it's oral, but still makes me a bit apprehensive about using it for a long course, certainly at 600mg BD.

#IDMastodon #MedMastodon #AMR #antibiotics #microbiology #medicine #linezolid

Prolonged use of linezolid in bone and joint infections: a retrospective analysis of adverse effects | Journal of Antimicrobial Chemotherapy | Oxford Academic https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkad276/7264092

Actually quite low risk of serotonin syndrome when using #Linezolid in patients on antidepressants!

#antibiotics #IDMastodon #microbiology #AMR #MedMastodon

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2799688

Good news:

- the risk of #serotonin syndrome is low in hospitalized older adults treated with #linezolid (around 0.5%)
- antidepressants do not increase the risk of serotonin syndrome in these patients

So, being on an #antidepressant should not be a contraindication to receiving linezolid and antidepressants do not need to be stopped when linezolid is prescribed.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2799688

#MedMastodon #GeriMastodon #Psychiatry