Postdoc position in locus coeruleus connectomics of resilience at MGH

Massachusetts General Hospital / Harvard Medical School

Exciting postdoc on #locuscoeruleus functional networks project in #Alzheimers in #Boston? Come join our fun, collaborative lab at MGH!

See the full job description on jobRxiv: https://jobrxiv.org/j...
https://jobrxiv.org/job/massachusetts-general-hospital-harvard-medical-school-27778-postdoc-position-in-locus-coeruleus-connectomics-of-resilience-at-mgh/?feed_id=57015

Postdoc position in locus coeruleus connectomics of resilience at MGH

Massachusetts General Hospital / Harvard Medical School

Exciting postdoc on #locuscoeruleus functional networks project in #Alzheimers in #Boston? Come join our fun, collaborative lab at MGH!

See the full job description on jobRxiv: https://jobrxiv.org/j...
https://jobrxiv.org/job/massachusetts-general-hospital-harvard-medical-school-27778-postdoc-position-in-locus-coeruleus-connectomics-of-resilience-at-mgh/?feed_id=53370

Postdoc position in locus coeruleus connectomics of resilience at MGH

Massachusetts General Hospital / Harvard Medical School

Exciting postdoc on #locuscoeruleus functional networks project in #Alzheimers in #Boston? Come join our fun, collaborative lab at MGH!

See the full job description on jobRxiv: https://jobrxiv.org/j...
https://jobrxiv.org/job/massachusetts-general-hospital-harvard-medical-school-27778-postdoc-position-in-locus-coeruleus-connectomics-of-resilience-at-mgh/?feed_id=52961

RT @MaraMather
New preprint! Five weeks of heart rate variability biofeedback affected structural volume in subregions of the hippocampus targeted by the locus coeruleus - noradrenergic system. #locuscoeruleus #HRV https://www.medrxiv.org/content/10.1101/2023.03.02.23286715v1

First, Mattia - at that time a Bachelor student in our 2-man-group - singlehandedly established optogenetics. The plan: stimulate the #LocusCoeruleus, run RNA-seq in the dorsal and ventral hippocampus (HC). But our simple plan quickly got complicated.

Wow! #locuscoeruleus #alzeimers

https://twitter.com/MikeKelberman/status/1620896852936908801?t=O4pWUpmSoiZD-0sRFiB2dg&s=19

Quick intro after switching from a different server to join the cool #neuroscience crowd! 👋​

My team is working on the acute stress response, with a focus on the mighty #LocusCoeruleus, #behavior and multiomics.

Back on the birdsite we started the ambitious tradition of science trailers. This was our first video back in 2020: #Rammstein and @Neuroscience. Volume to 11. 🔊​

I am excited to share my review paper on "The Contribution of the #LocusCoeruleus–#Noradrenaline System Degeneration during the Progression of #Alzheimer's Disease" 🤩 It is now online, you can check it out to learn latest updates😊 @DZNE_en
mdpi.com/2007082 @Biology_MDPI

RT @HeidiJacobsLab@twitter.com

! We have an open position for a PhD-student in early detection of Alzheimer's Disease at @MaastrichtU@twitter.com !! #locuscoeruleus More information here: https://www.academictransfer.com/en/320871/phd-candidate-10-fte-early-detection-of-alzheimers-disease-maastricht-university-alzheimer-center-limburg/

🐦🔗: https://twitter.com/HeidiJacobsLab/status/1599900653517561858

Check out what the #LocusCoeruleus is doing when a mouse mother is retrieving a pup, and the #noradrenaline it releases into the ACC!

Very cool new work by Steve Shea's team: https://www.biorxiv.org/content/10.1101/2022.12.04.519053v1

🔵 What regulates #pupil size at rest?

"These results suggest that spontaneous changes in pupil size that occur during states of rest can be used as a noninvasive general index of activity in ascending arousal system (AAS) nuclei. Importantly, the nature of pupil-AAS coupling during rest appears to be vastly different from the relatively slow canonical hemodynamic response function that has been used to characterize task-related pupil-AAS coupling."

We all know it's the #LocusCoeruleus... 🤫

🔵 What regulates #pupil size at rest?

"These results suggest that spontaneous changes in pupil size that occur during states of rest can be used as a noninvasive general index of activity in ascending arousal system (AAS) nuclei. Importantly, the nature of pupil-AAS coupling during rest appears to be vastly different from the relatively slow canonical hemodynamic response function that has been used to characterize task-related pupil-AAS coupling."

We all know it's the #LocusCoeruleus... 🤫

A series of extremely cool #locuscoeruleus manuscripts have been put out there recently, and I wanna take the opportunity to highlight them in this🧵

Would love input from other #bluespot enthusiasts, since I'm definitely missing papers!

Maybe we can keep adding by replying, and eventually create an easily accessible list of publications that currently shape the #LC field

🔵

#systemsneuro #neuroscience #noradrenaline #preprints

@maramather is here! And so the #LocusCoeruleus #neuroscience community grows! 👏💪

I am fascinated by the #brain 🧠, #neuroscience, #ageing, #Alzheimer's #dementia and #neurodegenerative #diseases - especially the #noradrenergic system of the #LocusCoeruleus ( #LC #bluespot 🔵🔵) and #vagusnervstimulation ⚡. Let's continue to exchange about it.

#introduction

Hello,

I am a neuroscientist studying how specific regions in the brain are vulnerable to Alzheimer's disease (#AD). We are mainly interested in the neurons of entorhinal cortex and hippocampal since they are affected early in AD and important for memory. We use in vivo electrophysiology to understand the population dynamics of neurons affected by amyloid beta and tau pathologies. More recently, we've been interested in how locus coeruleus pathology impacts downstream regions.
Was awesome meeting so many fellow scientists at the #neuroscience meeting #sfn2022

#neurodon #memory #alzheimers #dementia #entorhinalcortex #hippocampus #locuscoeruleus #sfn22

Oh hello there, my beautiful cells! #neuroscience #neuropeptide #locuscoeruleus #RNAscope #IHC

🔵If you also feel overwhelmed by all the amazing #LocusCoeruleus work being published these days, here's one you must not miss!

Our friends
@Sarah__Meissner
et al from
@NCMLabETH

show that LC activity can be regulated with pupil-based biofeedback!!

https://doi.org/10.1101/2022.08.26.505388

🔵 Nice work!!! Our #LocusCoeruleus community has two new Swiss members! BeckyJordan and Georg Keller show that the LC might broadcast a prediction error signal to gate cortical plasticity 🔥👇

https://twitter.com/BeckyJordan321/status/1590338197573148672?t=RRuzcv5pmunmGXNIrkvplQ&s=19

https://doi.org/10.1101/2022.11.08.515698

Alright, time for an #introduction :)

I am an "assistant" professor at the University of Nottingham, but will be moving to the University of Tilburg in two months.

My main interest is the #locuscoeruleus - both its role in adaptively modulating #cognition and its degeneration as an early step in #Alzheimers disease.

The methods I use include #pupillometry, #mri, #eeg and naturalistic driving tasks.

I also write software in #Java, #Python, and #Matlab.

My site: https://andrew.modelgui.org/