#Cardiomastodon #loopdiuretics cause measurable decreases in BV within hours of a single dose. Single doses of loop diuretics produce measurable changes in relative blood volume that follow distinct profiles for subjects with & without congestive #heartfailure When measured alongside urine output, these profiles may be used to estimate plasma refill rates — potential patient-specific targets for decongestive therapy across serial diuretic doses @CJCJournals