The EMBO Journal · @embojournal
460 followers · 221 posts · Server sciencemastodon.com
Regulation of #LRRK2 mRNA stability by ATIC and its substrate #AICAR through ARE-mediated mRNA decay in #Parkinson's disease
Yulan Xiong and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2022113410
OsteoarthriticAutistic she/her · @OsteoarthriticAutistic
85 followers · 871 posts · Server disabled.social‘Game-changing’ technique could identify Parkinson’s before symptoms show | The Independent
#Parkinsons
#ParkinsonsDiagnosis
#AlphaSyn
#AlphaSynSAA
#GBA
#LRRK2
#LossOfSmell
https://www.independent.co.uk/news/health/parkison-s-diagnosis-protein-study-symptoms-b2318504.html
#parkinsons #parkinsonsdiagnosis #alphasyn #alphasynsaa #gba #lrrk2 #lossofsmell
Thierry Galli · @tgalli
23 followers · 6 posts · Server mastodon.topWe found that the #Parkinson's disease related kinase #LRRK2 interacts with vesicular #SNAREs #VAMP4 and #VAMP7. #VAMP4 and #VAMP7 are required for proper processing and release of #Parkinson's disease #biomarkers #VGF as we found using #secretomics. We found late endosomal #secretion of #VGF together with #exosome markers like #CD63. We also developed a #rushassay to study #VGF #trafficking.
#parkinson #lrrk2 #snares #vamp4 #VAMP7 #biomarkers #vgf #secretomics #secretion #exosome #cd63 #rushassay #trafficking
Thierry Galli · @tgalli
23 followers · 5 posts · Server mastodon.top#Secretion of #VGF relies on the interplay between #LRRK2 and post-Golgi v-SNAREs #VAMP4 #VAMP7.
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00232-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124723002322%3Fshowall%3Dtrue
#secretion #vgf #lrrk2 #vamp4 #VAMP7
Thomas Sandmann · @thomas_sandmann
225 followers · 99 posts · Server genomic.social
New preprint from my colleagues at Denali: https://www.biorxiv.org/content/10.1101/2022.12.19.521070v1 They describe how the LRRK2 kinase, a risk factor for Parkinson's Disease regulates secretion of BMP, an endolysosomal lipid involved in glycosphingolipid (GSL) catabolism, from kidney into urine and modulates BMP and GSL levels in the brain. #neurodegeneration #lrrk2 #parkinsons #lipids #omics
#neurodegeneration #lrrk2 #parkinsons #lipids #omics
Sara Gomes · @gomesara
6 followers · 3 posts · Server mastodon.onlineGreat news: Denali Therapeutics first-in-class #LRRK2 tageted drug for #parkinsonsdisease advances into phase III. Getting closer to disease-modifying treatments! https://www.nature.com/articles/d41573-022-00212-0