#leukocytes in particular need to be recruited within short time frames because immunological threats arise at unpredictable sites in the body. Moreover, #Adaptiveimmunity is generated in #lymphatic organs, which are usually remote from the primary site of infection, requiring long-range cellular trafficking.
#dendriticcells can “self-shape” the chemotactic gradients that help them transport antigens to lymph nodes, @SciImmunology

I'm at the AGM for the #Lymphoedema Support Network today and have just found out there's apparently a lymphatic system around the brain which could have all kinds of implications for understanding Alzheimer's and those with lymphoedema - fascinating!

#lymphatic #brains #science!

What happens downstream of transcription factor #Prox1 during #transdifferentiation of embryonic venous #endothelial cells (VECs) into #lymphatic endothelial cells (LECs)?

Benjamin Hogan and colleagues use #singlecell profiling to reveal regulation of early events in #zebrafish #lymphangogenesis

https://www.embopress.org/doi/10.15252/embj.2022112590

Lymph Drainage for Ears
https://youtu.be/vAs9uFYvcrk

#massage #lymphatic

The blood #vasculature instructs #lymphatic patterning in a #SOX7-dependent manner
Vascular endothelial-specific transcription factor, SOX7, acts as a key driver of #dorsolateral patterning of lymphatic vessels during development by repressing #VEGFC transcription
Mathias Francois and coworkers, The Centenary Institute
https://www.embopress.org/doi/10.15252/embj.2021109032

Defects in this gene cause everything in the body to swell - even the #brain
#Mutations in the #FAT4 gene can cause #Hennekam syndrome, which is characterized by various abnormalities of the #lymphatic system
#Biology #Medical #sflorg
https://www.sflorg.com/2023/02/bio02012301.html

RT @daniyal_jafree@twitter.com

Super exciting work by @KusumbeLab@twitter.com using 3D imaging to demonstrate the presence and regenerative functions of #lymphatic vessels in bones! First the CNS, now this - new ways to study lymphatics are revealing these vessels to exist and function in the places we least expected 🧠🦴 https://twitter.com/kusumbelab/status/1616110055442579458

🐦🔗: https://twitter.com/daniyal_jafree/status/1616146574148501515

RT @HaoYin20@twitter.com

Ligand-receptor connectome identify lung arterial EC as the champion secretory EC: Notch ligands,
Ephrin B2, Endothelin 1, CXCL12, DKK2!👏

The runner-up is #Lymphatic EC: PDGFA, Sema3a, CCL21

This was yesterday's work, using #midjourney to help w/ generating the vessels.

The tedious part is getting the "extra" stuff out of the original #art & making it more varied rather than symmetrical.

Well, it turned better than I expected. Still...a work in progress.

#aiart #digitalart #lymphatic system #graphicdesign