Transcriptional and #chromatin profiling of human blood innate #lymphoid cell subsets sheds light on #HIV1 pathogenesis
Luban Lab and collaborators
https://www.embopress.org/doi/full/10.15252/embj.2023114153

Murine #COVID19 #lethality is characterized by #lymphoid depletion associated with suppressed #antigen presenting cell functionality https://ajp.amjpathol.org/article/S0002-9440(23)00119-0/fulltext?rss=yes

Protecting #tissues from #autoimmunity is a fascinating function of the immune system: in this new work on #innateimmunity in the salivary gland it is #lymphoid #NKcells that regulate #TCells and prevented autoimmunity via TRAIL-dependent elimination of CD4+ T cells. These NK cells show adaptive-like features with long-term residency in non-lymphoid tissues. #immunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2

Interesting study in #ScientificReports that did #transcriptome profiling of surgically-removed calcified aortic valves from patients with/without #ClonalHematopoiesis. The authors found broad changes to immune cell infiltrates but also to #antibody profiles that correlated with survival. This last point is cool because CH's impact on #myeloid biology is often discussed, but it can obviously have important effects on #lymphoid cells, too: https://www.nature.com/articles/s41598-022-24130-8 #science #medicine #cardiology